Wright(J R),Polvi(S),MacLean(H) Diabetes 1992-12-28

...FPGs were monitored 5 days/wk. Recipients remained normoglycemic (plasma glucose < 11.1 mM) for 50 days posttransplantat...

Jackman(A L),Newell(D R),Gibson(W),Jodrell(D… Biochem Pharmacol 1992-01-03

...FPGS) substrate activity demonstrated a Km of 40 microM for ICI 198583 and a Vmax/Km (relative to folic acid) of 3.5. Th...

McCloskey(D E),McGuire(J J),Russell(C A),Row… J Biol Chem 1991-05-01

...FPGS activity. The evidence supported decreased FPGS activity as the mechanism of resistance to short MTX exposure in th...

Jackman(A L),Marsham(P R),Moran(R G),Kimbell… Adv Enzyme Regul 1991-09-24

...FPGS substrate activity. Rapid cellular uptake and metabolism of polyglutamate forms that are approximately 100-fold mor...

Abraham(A),McGuire(J J),Galivan(J),Nimec(Z),… J Med Chem 1991-03-12

...FPGS) in vitro. All compounds inhibited recombinant human-dihydrofolate reductase (DHFR) at nearly equivalent magnitude ...

Li(S W),Nair(M G),Edwards(D M),Kisliuk(R L),… J Med Chem 1991-10-22

...FPGS) and striking differences in substrate activity were observed among these compounds, indicating that structural mod...

Moran(R G),Colman(P D),Jones(T R) Mol Pharmacol 1990-01-02

...FPGS. Several 5,8-dideazafolate derivatives that lack the 2-amino group had activity as substrates for FPGS equivalent t...

Harrap(K R),Jackman(A L),Newell(D R),Taylor(… Adv Enzyme Regul 1990-05-21

...FPGS, and the polyglutamate derivatives of CB3717, CB3804 and CB3819 are better TS inhibitors than the corresponding mon...

Jackson(M J),Surh(L C),O&#x27;Brien(W E),Beaudet(… Genomics 1990-05-29

...Fpgs, and Ak-1 whose linkage has been conserved between human chromosome 9q and mouse chromosome 2.

Bolanowska(W E),Russell(C A),McGuire(J J) Arch Biochem Biophys 1990-10-03

...FPGS was not altered by addition of NaHCO3. The potency of 5,8-dideazapteroylornithine, an FPGS-specific inhibitor, was ...