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Computational identification of putative mRNA-miRNA signatures in chemoresist...

Farajzadeh-Dehkordi(M),Rezvani Boroujeni(E... Biochem Biophys Rep 2026-06-00

...LYN genes, as well as miR-16-2-3p, were significantly overexpressed, while the XBP1 gene and miR-5684 were markedly down...

Novel BTK inhibitors and degraders for relapsed/refractory CLL/SLL: latest up...

Sharma(P),Jiang(H),Liu(D) J Hematol Oncol 2026-06-07

...LYN/BTK inhibitor, showed a high objective response rate in patients with prior exposure to BTKi, BCL-2 inhibitors, and ...

EGR1 regulates degranulation and mediator release in C48/80-induced pseudo-al...

Sun(Y),Li(H),Li(J),Wang(Y),Long(T),Cui(Z),... Immunol Res 2026-05-30

...Lyn, Syk, ERK1/2, and AKT in C48/80-stimulated RBL-2H3 cells, and alleviated tissue edema and inflammatory cell infiltra...

The protein tyrosine phosphatase CD45 promotes PMN transepithelial migration,...

Miranda(J),Fink(DJ),Wilson(ZS),Hilgarth(R)... JCI Insight 2026-08-10

...Lyn. Together, these data highlight an important CD45/CD11b/Lyn signaling axis that regulates PMN trafficking and effect...

A core innate immune gene panel derived from germ-free larval zebrafish trans...

Liu(XR),Liu(Y),Zhang(CC),Huang(ZS),Guo(FY)... Fish Shellfish Immunol 2026-09-00

...lyn, and mxc as convergent hubs; together with il1b and saa, these genes formed a six-gene panel. Compared with CONR lar...

Constraining regulatory domain dynamics of the Src kinase Fgr increases ATP-s...

Gonzalez-Areizaga(G),Shu(ST),Alvarado(JJ),... Cell Rep 2026-06-23

...Lyn, and Fgr. Their modular SH3 and SH2 domains regulate kinase activity and signal transduction. Here, we show that reg...

Lysozyme-Associated Nephropathy in Myeloid Neoplasms: A Clinicopathological a...

Matsumoto(M),Yamamoto(S),Shinkawa(K),Matsu... Nephron 2026-06-16

...LyN. To further investigate LyN pathophysiology, we performed the first mass spectrometry-based proteomic analysis of pr...

Neuro-glioma activity-dependent growth mechanisms: an actionable circuit from...

Tian(YF),Fan(JY),Wu(Q),Pu(J) Transl Cancer Res 2026-05-30

...LYN proto-oncogene, Src family tyrosine kinase (LYN), phosphoinositide 3-kinase (PI3K)-mechanistic target of rapamycin (...

Integrated bioinformatics and machine learning for shared diagnostic genes an...

Wang(Q),Fang(C) Clin Rheumatol 2026-07-00

...LYN) were identified among the 12 genes shared between DEGs and WGCNA using machine learning. RT-qPCR analysis confirmed...

Lyn attenuates cisplatin-induced acute kidney injury by inhibition of RIPK1-m...

Li(N),Zhang(H),Peng(L),Liu(J),Lin(G),Sun(J... Biochem Pharmacol 2026-09-00

...Lyn in CP-AKI, as well as the possible mechanism. Here, we found that Lyn was down-regulated in mice with CP-AKI. Knocko...

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