Rumberger(B G),Barrueco(J R),Sirotnak(F M) Cancer Res 1990-08-23

...FPGS. Values for Vmax (derived with partially purified FPGS) for the other 4-aminofolate analogues and folic acid were s...

Antonsson(B),Barredo(J),Moran(R G) Anal Biochem 1990-07-26

...FPGS on small tissue samples and is amenable with the assay of FPGS in cell sonicates. Typically, blank values of 100-20...

Rumberger(B G),Schmid(F A),Otter(G M),Sirotn… Cancer Commun 1990-11-08

...FPGS) activity. Clonal derivatives of these 7 EDX-resistant cell lines exhibited 2- to 28-fold reductions in FPGS activi...

Rosowsky(A),Forsch(R A),Moran(R G) J Med Chem 1989-04-06

...FPGS inhibition was observed even though N5,N8, and N10 in H4PteOrn were replaced by carbon. Binding to FPGS thus appear...

Banerjee(R V),Shane(B),McGuire(J J),Coward(J… Biochemistry 1989-05-01

...FPGS) isolated from Escherichia coli, hog liver, and rat liver and for dihydrofolate synthetase (DHFS) isolated from E. ...

McGuire(J J),Bolanowska(W E),Piper(J R) Biochem Pharmacol 1988-11-25

...FPGS. It was a much more potent linear competitive inhibitor of human FPGS than the corresponding methotrexate derivativ...

Firth(R G) Prim Care 1988-12-12

...FPGs and HbA1c concentrations in mild to moderately severe NIDDM. Both can reduce insulin resistance and both increase i...

Rosowsky(A),Moran(R G),Freisheim(J H),Bader(… NCI Monogr 1988-03-04

...FPGS). One of these compounds, the Orn analog of AMT, is the most potent FPGS inhibitor we have found to date. A model t...

Moran(R G),Colman(P D),Harvison(P J),Kalman(… Biochem Pharmacol 1988-06-29

The similarity between the reactions catalyzed by folylpoly-gamma-glutamate synthetase (FPGS), gamma-glutamylcysteine sy...

Rosowsky(A),Forsch(R A),Moran(R G),Kohler(W)… J Med Chem 1988-08-05

...FPGS. Deletion of the alpha-carboxyl also led to diminished anti-FPGS activity in comparison with previously studied hom...