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The cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bod…

de Thé(H),Le Bras(M),Lallemand-Breitenbach(V) J Cell Biol 2012-07-09

...RARA oncoprotein and, together, cure APL. Analysis of arsenic-induced PML or PML/RARA degradation has implicated oxidati...

TTMV::RARA-positive acute promyelocytic leukemia with marrow necrosis and centr…

Wang(Z),Chen(J),Meng(J),Zhao(M),Liu(H),Xiao(… J Clin Exp Hematop 2024-00-00

Since the identification of the TTMV::RARA fusion in pediatric cases resembling acute promyelocytic leukemia (APL) by As...

Amplification of ERBB2, RARA, and TOP2A genes in a myelodysplastic syndrome tra…

Martín-Subero(JI),Harder(L),Gesk(S),Schoch(R… Cancer Genet Cytogenet 2001-06-00

...RARA, and TOP2A genes. The median copy number of ERBB2, RARA, and TOP2A genes in the tumor cells was six (range: 4--10)....

[The Significance of Genetic Testing for Acute Promyelocytic Leukemia].

Satoh(Y),Masuda(A),Yatomi(Y) Rinsho Byori 2017-00-00

...RARA mRNA. All-trans retinoic acid (ATRA) is a representa- tive molecular-targeted drug and is directed against PML-RARA...

Reduction of heparan sulphate-associated anionic sites in the glomerular baseme…

van den Born(J),van Kraats(AA),Bakker(MA),As… Diabetologia 1995-10-00

...rara interna, and were significantly smaller than those in the lamina rara externa of the glomerular basement membrane (...

Cross-Database Analysis Reveals Sensitive Biomarkers for Combined Therapy for E…

Xiang(Z),Huang(X),Wang(J),Zhang(J),Ji(J),Yan… Front Pharmacol 2018-00-00

...RARA. The expression of RARA, THRA, and CACNB1 were negatively correlated with Myc activation, while ERBB2 and TOP2A pos...

Evidence for direct involvement of epirubicin in the formation of chromosomal t…

Mays(AN),Osheroff(N),Xiao(Y),Wiemels(JL),Fel… Blood 2010-01-14

Therapy-related acute promyelocytic leukemia (t-APL) with t(15;17)(q22;q21) involving the PML and RARA genes is associat...

Clinical and genomic characterization of an ATRA-insensitive acute promyelocyti…

Kirkham(JK),Liu(YC),Foy(SG),Ma(J),Gheorghe(G… Genes Chromosomes Cancer 2023-00-00

...RARA) fusion is the hallmark of acute promyelocytic leukemia (APL) and is observed in over 95% of APL cases. RARA and ho...

Problems existing in differentiation therapy of acute promyelocytic leukemia (A…

Wang(ZY),Chen(Z),Huang(W),Li(XS),Lu(JX),Huan… Blood Cells 1993-00-00

...RARA fusion gene was detected in 45 cases, one had a variant translocation t(11;17) bearing fusion gene PLZF-RARA, one p...

Effect of all-trans retinoic acid and arsenic trioxide on tissue factor express…

Guo(W),Wang(H),Zhao(W),Zhu(J),Ju(B),Wang(X) Chin Med J (Engl) 2001-01-00

...RARa + U937 may be related to the fusion protein PML-RARa. The down-regulating effect of ATRA and As2O3 on TF expression...

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