Rosowsky(A),Bader(H),Cucchi(C A),Moran(R G),… J Med Chem 1988-08-05

N delta-Acyl derivatives of the potent folylpolyglutamate synthetase (FPGS) inhibitor N alpha-(4-amino-4-deoxypteroyl)-L...

Rosowsky(A),Bader(H),Forsch(R A),Moran(R G),… J Med Chem 1988-05-10

...FPGS) from mouse liver. Furthermore, inhibition of folic acid polyglutamylation in vitro at equimolar 500 microM concent...

Rosowsky(A),Bader(H),Kohler(W),Freisheim(J H… J Med Chem 1988-08-05

...FPGS). Activity was correlated with the number of CH2 groups in the side chain. The IC50's for inhibition of cell growth...

Moran(R G),Colman(P D),Rosowsky(A) NCI Monogr 1988-03-04

The activity of mouse-liver folylpolyglutamate synthetase (FPGS) was compared using a number of folates and folate analo...

McGuire(J J),Piper(J R),Coward(J K),Galivan(… NCI Monogr 1988-03-04

...FPGS). Folylpolyglutamates are absolutely essential for cell survival and proliferation. MTX polyglutamates are strongly...

Johnson(T B),Nair(M G),Galivan(J) Cancer Res 1988-05-18

...FPGS activity. This conclusion is consistent with the proposition that the metabolism of slow-acting substrates for FPGS...

Sussman(D J),Milman(G),Shane(B) Somat Cell Mol Genet 1987-01-14

...FPGS) responsible for adding polyglutamates to folic acid. The human gene for FPGS was introduced into AUX B1 cells by c...

Clarke(L),Waxman(D J) Arch Biochem Biophys 1987-09-17

...FPGS rapidly inactivated at 37 degrees C (t1/2 approximately 8 min), whereas FPGS isolated from rabbit liver was signifi...

Clarke(L),Rosowsky(A),Waxman(D J) Mol Pharmacol 1987-02-24

Folylpolyglutamate synthetase (FPGS) catalyzes the gamma-glutamylation of both folates and folate antagonists and has be...

Sussman(D J),Milman(G),Osborne(C),Shane(B) Anal Biochem 1987-03-13

...FPGS into AUX B1 cells restores the activity of the thymidylate synthase pathway and demonstrates that the E. coli FPGS ...