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Draper/CED-1 mediates an ancient damage response to control inflammatory blood …

Evans(Iwan Robert),Rodrigues(Frederico S L M… Curr Biol 0000-00-00

...Syk-signaling pathway used in vertebrate adaptive immune responses. Consequently, our results suggest that adaptive immu...

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-…

Sochalska(M),Ottina(E),Tuzlak(S),Herzog(S),H… Cell Death Differ 0000-00-00

...Syk) and Brutons tyrosine kinase (Btk). As such, A1 represents a putative target for the treatment of B-cell-related pat...

Inhibition of AMPK through Lyn-Syk-Akt enhances FcεRI signal pathways for aller…

Lin(Kai-Chun),Huang(Duen-Yi),Huang(De-Wei),T… J Mol Med (Berl) 0000-00-00

...Syk-Akt. When AMPK was activated by AICAR, A769662 and metformin, FcεRI-mediated Syk, ERK, JNK and p38 activation, and T...

Spleen Tyrosine Kinase Mediates EGFR Signaling to Regulate Keratinocyte Termina…

Wu(Nan-Lin),Huang(Duen-Yi),Wang(Li-Fang),Kan… J Invest Dermatol 0000-00-00

...Syk are under development for inflammatory diseases. Syk expression in the skin has been detected, but its functions in ...

A PREVIOUSLY UNKNOWN UNIQUE CHALLENGE FOR INHIBITORS OF SYK ATP-BINDING SITE: R…

Uckun(Fatih M),Ma(Hong),Ozer(Zahide),Goodman… EBioMedicine 0000-00-00

...SYK as a molecular target in B-lineage leukemia/lymphoma cells prompted the development of SYK inhibitors as a new class...

Concomitant high expression of Toll-like receptor (TLR) and B-cell receptor (BC…

Akhter(Ariz),Street(Lesley),Ghosh(Sunita),Bu… Hematol Oncol 0000-00-00

...SYK/BLNK/CARD11/PLCG signalosome and lower expression of MALT1/BCL10 genes suggested tonic pattern of BCR activation. Am...

Interleukin-6 and chondrocyte mineralisation act in tandem to promote experimen…

Nasi(Sonia),So(Alexander),Combes(Christèle),… Ann Rheum Dis 0000-00-00

...Syk and PI3 kinases, Jak2 and Stat3 molecules. Exogenous IL-6 promoted calcium-containing crystal formation and upregula...

Evaluation of the Wilma-SIE Virtual Screening Method in Community Structure-Act…

Hogues(Hervé),Sulea(Traian),Purisima(Enrico … J Chem Inf Model 0000-00-00

...Syk), and a nucleotide methyltransferase (TrmD) were included. Pose selection was achieved with high precision; in all 2...

A FRET-Based Biosensor for Imaging SYK Activities in Living Cells.

Xiang(Xue),Sun(Jie),Wu(Jianhua),He(Hai-Tao),… Cell Mol Bioeng 0000-00-00

...SYK substrate VAV2, and a C-terminal YPet. Upon the specific phosphorylation by SYK , the biosensor substrate peptide bo...

Comparison of innate immunity mediators in peritoneal fluid and spleen between …

Choi(Young Joon),Yeo(Seung Geun),Kim(Young I… Aging Clin Exp Res 0000-00-00

...Syk were increased in the spleen (p < 0.05). In young rats, TLR 2/4, dectin-1, and Trem-1 were increased in peritoneal f...

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