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Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer …

Martin(Paul),Gillen(Michael),Millson(David),… Drugs R D 0000-00-00

...SYK) inhibitor. The active metabolite of fostamatinib, R406, is primarily metabolized by CYP3A4.,The aim of this study w...

Identification of novel genes and pathways in carotid atheroma using integrated…

Nai(Wenqing),Threapleton(Diane),Lu(Jingbo),Z… Sci Rep 0000-00-00

...SYK, LYN and PTPN6 may play critical roles in the network. Additionally, similar observations were seen in a validation ...

Comparison of innate immunity mediators in peritoneal fluid and spleen between …

Choi(Young Joon),Yeo(Seung Geun),Kim(Young I… Aging Clin Exp Res 0000-00-00

...Syk were increased in the spleen (p < 0.05). In young rats, TLR 2/4, dectin-1, and Trem-1 were increased in peritoneal f...

Integration of Ligand and Structure Based Approaches for CSAR-2014.

Prathipati(Philip),Mizuguchi(Kenji) J Chem Inf Model 0000-00-00

...SYK), and tRNA (guanine-N(1))-methyltransferase (TrmD). Our docking and scoring workflow incorporates compound clusterin...

Insights into the allosteric regulation of Syk association with receptor ITAM, …

Feng(Chao),Post(Carol Beth) Phys Chem Chem Phys 0000-00-00

...Syk tyrosine kinase, regulates the binding affinity for association of Syk with doubly-phosphorylated ITAM regions of th...

A Computational Study of the Effects of Syk Activity on B Cell Receptor Signali…

McGee(Reginald L),Krisenko(Mariya O),Geahlen… Processes (Basel) 0000-00-00

...Syk (Syk-AQL) have better elucidated its role, but have not completely characterized its behavior. We present a computat...

Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cell…

Sinha(Meenal),Lowell(Clifford A) Am J Respir Cell Mol Biol 0000-00-00

...Syk in either ATII cells or mTECs, which is in contrast to earlier published reports. Both cell types expressed C-type l...

Dextran sulfate triggers platelet aggregation via direct activation of PEAR1.

Vandenbriele(Christophe),Sun(Yi),Criel(Maart… Platelets 0000-00-00

...Syk signaling and via a Syk-independent SFK/PI3K/Akt-dependent tyrosine kinase pathway in human and murine platelets. Th...

Interleukin-6 and chondrocyte mineralisation act in tandem to promote experimen…

Nasi(Sonia),So(Alexander),Combes(Christèle),… Ann Rheum Dis 0000-00-00

...Syk and PI3 kinases, Jak2 and Stat3 molecules. Exogenous IL-6 promoted calcium-containing crystal formation and upregula...

Spleen tyrosine kinase (SYK) is a potential target for the treatment of cutaneo…

Braegelmann(Christine),Hölzel(Michael),Ludbr… Exp Dermatol 0000-00-00

...SYK. SYK-associated genes are strongly upregulated in CLE skin lesions. Importantly, phosphorylated SYK (pSYK) is strong...

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