Glennie(L),Huang(DT) Mol Cell 2026-08-06

...SPOP that can become dysregulated in cancer. SPOP oligomers form inactive double donuts or active linear filaments, as s...

Hassell(LA),Gallati(M),Thoma(M),Asfaw(S),Har… MicroPubl Biol 2026-00-00

...spop-1 , suggesting that SPOP-1-dependent pathways are also involved in glutamatergic neuron degeneration.

Pan(X),Wang(Y),Luo(J),Dai(X),Zhang(J),Zheng(… Am J Cancer Res 2026-00-00

...SPOP-mediated ubiquitination and proteasomal degradation. In vivo, METTL16 promotes colon cancer xenograft growth while ...

Mirskaya(M),Isaksson(A),Lindgren(EC),Carlsso… Int Urogynecol J 2026-02-00

...sPOP; 1617 (28.3%) women with sPOP and 6669 (17.8%) women without sPOP rated their health as poor. sPOP was associated w...

Yang(X),Zhou(Y),Huang(Q),Wang(L),Zhang(S),Ya… Oncogene 2026-08-00

...SPOP and p62/SQSTM1, and disrupting the interaction between SPOP, p62/SQSTM1 and nuclear ubiquitination may be a potenti...

Zhu(Z),Hahn(Q),Turbiville(LE),Liu(P) Sci Signal 2026-06-23

...SPOP, thereby protecting STING from degradation. Upon stimulation of STING with an agonist or dsDNA, Cdh1 bound to STING...

Zhang(J),Liu(R),Han(X),Jiao(Y),Peng(Y),Zhou(… Proc Natl Acad Sci U S A 2026-06-16

...SPOP has been identified as a promising E3 ligase target in LUAD. SPOP is downregulated in LUAD samples and associated w...

Wendt(JR),Adams(KM),Moreno(R),Hossan(MS),Str… bioRxiv 2026-07-10

...SPOP, PPP2R1A, KMT2D), we identified additional variants in TSC2, NCOR2, and CTNNA2 that are predicted to be likely path...

Mercinelli(C),Di Costanzo(F),Oing(C),Guandal… Expert Rev Anticancer Ther 2026-07-02

...SPOP mutations, TMPRSS2/ERG fusions, PTEN/PI3K/AKT pathway alterations, and novel therapeutic targets such as STEAP1, DL...

Chen(F),Li(Q),Gu(Q),Leo(J),Liang(X),Mehta(N)… Nat Commun 2026-06-30

...SPOP/CHD1 co-deficient tumors to ferroptosis-inducing therapy. Our findings establish SPOP/CHD1 as upstream genetic regu...