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Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antif…

Wevers(Brigitte A),Kaptein(Tanja M),Zijlstra… Cell Host Microbe 2015-01-12

...Syk-CARD9-mediated PKB signaling, that leads to loss of nuclear IRF1 activity, hence blocking IL12A transcription. The a...

Optimal aggregation of FcεRI with a structurally defined trivalent ligand overr…

Mahajan(Avanika),Barua(Dipak),Cutler(Patrick… ACS Chem Biol 2015-02-26

...Syk to override phosphatase-mediated negative regulatory signals.

Increased frequency of a unique spleen tyrosine kinase bright memory B cell pop…

Fleischer(Sarah J),Giesecke(Claudia),Mei(Hen… Arthritis Rheumatol 2015-02-19

...Syk (Syk++) was found in SLE patients. CD27-Syk++ B cells showed enhanced basal expression of p-Syk and stronger Syk pho...

The novel role of peroxiredoxin-2 in red cell membrane protein homeostasis and …

Matté(Alessandro),Pantaleo(Antonella),Ferru(… Free Radic Biol Med 2015-08-25

...Syk pathway; (ii) increased band 3 Tyr phosphorylation, with clustered band 3; and (iii) increased heat shock protein (H...

Infection with human rhinovirus 16 promotes enhanced IgE responsiveness in baso…

Agrawal(R),Wisniewski(J),Yu(M D),Kennedy(J L… Clin Exp Allergy 2015-08-14

...Syk, were increased on day 4 (P < 0.05), and elevated levels were also detected three weeks post-challenge.,Circulating ...

Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis…

Sprissler(C),Belenki(D),Maurer(H),Aumann(K),… Blood Cancer J 2015-09-16

...SYK containing oncogenes, SYK(wt), TEL-SYK and IL-2-inducible T-cell kinase (ITK)-SYK revealed a general myeloexpansion ...

Global analysis of neutrophil responses to Neisseria gonorrhoeae reveals a self…

Sintsova(Anna),Sarantis(Helen),Islam(Epshita… PLoS Pathog 2015-12-08

...Syk-, PKCδ- and Tak1-dependent signaling cascade that results in the activation of an NF-κB-dependent transcriptional re...

T cell receptor-associated protein tyrosine kinases: the dynamics of tolerance …

Barrera-Vargas(Ana),Gómez-Martín(Diana),Alco… Hum Immunol 2015-06-22

...Syk, which are PTKs with a major role in proximal signaling, all present abnormal functioning that contributes to an alt...

Macromolecular assembly of the adaptor SLP-65 at intracellular vesicles in rest…

Engelke(Michael),Pirkuliyeva(Sona),Kühn(Juli… Sci Signal 2015-05-12

...Syk (spleen tyrosine kinase) to phosphorylated motifs in BCR signaling subunits. By contrast, the subcellular targeting ...

HIV-1 induces B-cell activation and class switch recombination via spleen tyros…

Perisé-Barrios(Ana Judith),Correa-Rocha(Rafa… AIDS 2015-06-01

...SYK) and c-Jun N-terminal kinase (JNK) pathways.,Therefore, we showed that HIV-1 could directly induce primary B-cell de...

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