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Therapy-induced PML/RARA proteolysis and acute promyelocytic leukemia cure.

Nasr(R),Lallemand-Breitenbach(V),Zhu(J),Guil… Clin Cancer Res 2009-10-15

...RARA moiety of the fusion, whereas arsenic targets its PML part. PML/RARA expression in the mouse is sufficient to initi...

Bacillus subtilis RarA forms damage-inducible foci that scan the entire cell.

Hernández-Tamayo(R),Graumann(PL) BMC Res Notes 2019-04-11

...RarA-mVenus fusion to visualize the dynamics of RarA during conditions that generate DNA damage. In exponentially growin...

The Escherichia coli serS gene promoter region overlaps with the rarA gene.

Jain(K),Stanage(TH),Wood(EA),Cox(MM) PLoS One 2022-00-00

...RarA function. Further work revealed that most of the effects reflected the presence of sequences in the rarA gene that ...

Bacillus subtilis RarA Acts as a Positive RecA Accessory Protein.

Romero(H),Serrano(E),Hernández-Tamayo(R),Car… Front Microbiol 2020-00-00

...rarA ΔrecU and ΔrarA ΔrecX double mutant cells, and was blocked in ΔrarA recF15 cells. These results suggest that RarA c...

BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11…

Yamamoto(Y),Tsuzuki(S),Tsuzuki(M),Handa(K),I… Blood 2010-11-18

...RARA was found to possess common features with other RARA fusion proteins. These included: (1) the same break point in R...

[The significance of expression of isoforms RARa1 and RARa2 in response to medi…

Kalitin(NN),Buravtsova(IV) Klin Lab Diagn 2016-08-00

...RARa - isoforms RARa and RARa - in pathogenesis of solid and non-solid tumors, including multiple myeloma. The actual da...

Acute promyelocytic leukemia with t(15;16;17;19) and unusual fluorescence in si…

Kamal(NR),Hanson(CA),Dewald(GW) Cancer Genet Cytogenet 1996-11-00

...RARA-PML fusion was not evident by FISH, but the RARA signal was split in 74.5% of cells. GTL-banding and FISH with prob...

A sumoylation site in PML/RARA is essential for leukemic transformation.

Zhu(J),Zhou(J),Peres(L),Riaucoux(F),Honoré(N… Cancer Cell 2005-02-00

...RARA moieties of PML/RARA homodimers. Unexpectedly, we show that the K160 sumoylation site in the PML moiety of PML/RARA...

The genetics and clinical characteristics of children morphologically diagnosed…

Zhao(J),Liang(JW),Xue(HL),Shen(SH),Chen(J),T… Leukemia 2019-00-00

...RARA rearrangement (including 94 with PML-RARA and one with NPM-RARA) and two samples with KMT2A rearrangement. In the e...

The DNA binding property of PML/RARA but not the integrity of PML nuclear bodie…

Liu(X),Yuan(H),Peres(L),Chen(S),Chen(Z),de T… PLoS One 2014-00-00

...RARA mutants, were deficient in colony formation. Further experiments showed that DNA-binding-defective PML/RARA mutants...

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