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Impact of light-dark cycle on the expression of circadian clock genes, electroc…

Chen(YL),Lin(PT),Yang(MY),Chuang(JH) Int J Cardiol 2025-10-15

...Rorc downregulation and Nr1d1 upregulation at 24 weeks. Mitochondrial dysfunction, fibrosis, and inflammation markers we...

Monocyte-driven IFN and TNF programs orchestrate inflammatory networks in antis…

Fan(Y),Zhang(W),Su(M),Zheng(S),Lin(J),Zheng(… Front Immunol 2025-00-00

...RORC, and SMAD1 drive inflammatory and profibrotic signatures via the IL-17, JAK-STAT, and TGF-β pathways. This study id...

Integrative multi-omics analysis identifies genetically supported druggable tar…

Gu(SC),Zeng(SL),Zhang(W),Shen(CY),Yuan(CX),S… J Genet Eng Biotechnol 2025-12-00

...RORC), and Tumor Necrosis Factor Receptor Superfamily Member 25 (TNFRSF25) as potential drug targets for IBD and its sub...

[Expression of regulatory T cells and Th17 cells in idiopathic thrombocytopenic…

Guo(Ning-Hong),Shi(Qing-Zhi),Hua(Jian-Yuan),… Zhonghua Xue Ye Xue Za Zhi 2016-04-23

...RORc mRNA with RT-PCR in 29 newly diagnosed ITP patients and 28 healthy controls.,The ratio of CD4(+)CD25(+)T cells/CD4(...

Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective R…

Fauber(Benjamin P),Gobbi(Alberto),Robarge(Ki… Bioorg Med Chem Lett 2016-03-08

...RORc, or NR1F3) is a promising target for the treatment of autoimmune diseases. RORc is a critical regulator in the prod...

The role of IL-23/Th17 pathway in patients with primary immune thrombocytopenia.

Ye(Xin),Zhang(Lei),Wang(Hui),Chen(Yan),Zhang… PLoS One 2016-01-15

...RORC. In addition, elevated Th17 cells and plasma IL-17, IL-23 levels were also observed in these ITP patients. Furtherm...

Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists.

Fauber(Benjamin P),Gobbi(Alberto),Savy(Pasca… Bioorg Med Chem Lett 2016-05-23

...RORc inverse agonist activity and RORc cellular potencies. These improved N-sulfonyl-tetrahydroquinoline compounds also ...

Polycyclic aromatic hydrocarbons reciprocally regulate IL-22 and IL-17 cytokine…

Plé(Coline),Fan(Ying),Ait Yahia(Saliha),Vorn… PLoS One 2016-03-31

...RORC were down regulated, whereas AhR target gene CYP1A1 was upregulated. IL-22 induction by DEP-PAH was mainly dependen...

Copy number variants and genetic polymorphisms in TBX21, GATA3, Rorc, Foxp3 and…

Liao(Dan),Hou(Shengping),Zhang(Jun),Fang(Jin… Sci Rep 2016-01-06

...Rorc and Foxp3 were examined by real-time PCR and cytokine production was measured by ELISA. High Rorc CNV was associate...

Basal level of Th17 immune response is not enhanced in aplastic amemia.

Zhang(Jizhou),Wu(Qingqing),Yao(Jianfeng),Nie… Cytokine 2016-03-18

...RORC in circulating CD4(+) T cells, were not increased in AA. These results suggest that Th17 immune response may not pl...

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