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Systems pharmacology assessment of the 5-fluorouracil pathway.

Muhale(Filipe A),Wetmore(Barbara A),Thomas(R… Pharmacogenomics 2011-07-20

...FPGS, GGH, NME1, NT5C, RRM1, TYMS, UCK2, UNG and UMPS).,The RNAi screening strategy enabled prioritization of the genes ...

The plastidial folylpolyglutamate synthetase and root apical meristem maintenan…

Srivastava(Avinash C),Tang(Yuhong),de la Gar… Plant Signal Behav 2011-11-28

...FPGS) catalyzes the attachment of glutamate residues to the folate molecule in plants. Three isoforms of FPGS have been ...

Molecular determinants of folate levels after leucovorin administration in colo…

Sadahiro(Sotaro),Suzuki(Toshiyuki),Maeda(Yuj… Cancer Chemother Pharmacol 2010-02-05

...FPGS) gene expression, low gamma-glutamyl hydrolase (GGH) gene expression and low ATP-binding cassette sub-family C, num...

Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by …

Nannizzi(Sara),Veal(Gareth J),Giovannetti(El… Cancer Chemother Pharmacol 2010-07-13

...FPGS) and blocks folate metabolism and DNA synthesis by inhibiting TS, dihydrofolate reductase (DHFR) and glycinamide ri...

A monoclonal antibody for detection of folylpolyglutamate synthetase in paraffi…

Quinn(Amy E),Pinkney(Michael),Piggott(Nigel … Hybridoma (Larchmt) 2010-03-22

...FPGS) are key elements in the folate pathway. The role of FPGS is to add glutamate residues to folates and antifolates, ...

Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate …

Wang(Ping),Wang(Qi),Yang(Yonghong),Coward(Ja… Mol Biochem Parasitol 2010-07-22

...FPGS) as a single bifunctional protein. The two activities contribute to the essential pathway of folate biosynthesis an...

Significance of thymidylate synthase for resistance to pemetrexed in lung cance…

Ozasa(Hiroaki),Oguri(Tetsuya),Uemura(Takehir… Cancer Sci 2010-03-30

...FPGS) genes. TS gene expression was significantly increased in PC6/MTA-1.6 and PC6/MTA-4.0 cells relative to parental ce...

Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular ac…

Leclerc(G J),Mou(C),Leclerc(G M),Mian(A M),B… Leukemia 2010-03-30

...FPGS and other folate-related genes. HDACIs increased FPGS mRNA expression by 2- to 5-fold, whereas DHFR and TS mRNA exp...

Genes involved with folate uptake and distribution and their association with …

Figueiredo(Jane C),Levine(A Joan),Lee(Won H)… Cancer Causes Control 2010-08-10

...FPGS, GGH and SLC19A1, using 1,750 population-based and 245 clinic-based cases of pathologically confirmed colorectal ca...

Correlation between polymorphisms of the reduced folate carrier gene (SLC19A1) …

Adjei(Araba A),Salavaggione(Oreste E),Mandre… J Thorac Oncol 2010-12-14

...FPGS, GGH, and SLC19A1 genes. Patients with various genotypes were compared for efficacy and adverse events resulting fr...

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