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The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia.

Catalano(A),Dawson(MA),Somana(K),Opat(S),Sch… Blood 2007-12-01

...RARA amplified 2 transcript splice variants of a PRKAR1A-RARA fusion gene, and PRKAR1A and RARA FISH probes confirmed th...

Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute…

Chim(CS),Wong(SY),Pang(A),Chu(P),Lau(JS),Won… Leukemia 2005-12-00

...RARalpha2, confirming that RARA methylation collaborated with PML/RARA in totally suppressing RARalpha. In APL, RARA P2 ...

Mutational profile of ZBTB16-RARA-positive acute myeloid leukemia.

Fabiani(E),Cicconi(L),Nardozza(AM),Cristiano… Cancer Med 2021-00-00

...RARA+AML, 103 non-RARA rearranged AML, and 46 APL. The seven ZBTB16-RARA-positive patients were then screened for additi...

Dimerization-induced corepressor binding and relaxed DNA-binding specificity ar…

Zhou(J),Pérès(L),Honoré(N),Nasr(R),Zhu(J),de… Proc Natl Acad Sci U S A 2006-06-13

...RARA) oncogene. PML-enforced RARA homodimerization allows the tighter binding of corepressors, silencing RARA target gen...

Use of tamibarotene, a potent and selective RARα agonist, in combination with a…

Stein(EM),de Botton(S),Cluzeau(T),Pigneux(A)… Leuk Lymphoma 2023-00-00

...RARA overexpression using a blood-based biomarker test that measures RARA expression in peripheral blasts. A phase 2 stu...

Multi-omics and machine learning reveal context-specific gene regulatory activi…

Villiers(W),Kelly(A),He(X),Kaufman-Cook(J),E… Nat Commun 2023-00-09

...RARA binding on gene expression and regulation in an inducible PML::RARA cell line model and APL patient ex vivo samples...

PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leuk…

Cole(Christopher B),Verdoni(Angela M),Ketkar… J Clin Invest 2016-06-17

...RARA mice, which express PML-RARA in early hematopoietic progenitors and myeloid precursors, with or without DNMT3A. We ...

Treatment of STAT5b-RARA positive acute promyelocytic leukemia by Venetoclax co…

Zhang(G),Song(Y),Wan(L),Liu(K),Qiu(S),Wang(J… Blood Sci 2022-04-00

...RARA gene, who were called variant APL caused by RAR family (RARA, RARB, and RARG) and partner genes. STAT5b-RARA was a ...

The retinoic acid receptor alpha (RARA) gene is not associated with myopia, hyp…

Veerappan(S),Schäche(M),Pertile(KK),Islam(FM… Mol Vis 2009-07-17

...RARA is associated with myopia we have undertaken a case-control study assessing for associations between RARA and myopi...

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA d…

Nasr(R),Guillemin(MC),Ferhi(O),Soilihi(H),Pe… Nat Med 2008-12-00

...RARA mouse APL in vivo. Retinoic acid treatment of mouse APLs expressing the fusion protein PLZF-RARA triggers full diff...

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