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Molecular determinants of folate levels after leucovorin administration in colo…

Sadahiro(Sotaro),Suzuki(Toshiyuki),Maeda(Yuj… Cancer Chemother Pharmacol 2010-02-05

...FPGS) gene expression, low gamma-glutamyl hydrolase (GGH) gene expression and low ATP-binding cassette sub-family C, num...

Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate …

Wang(Ping),Wang(Qi),Yang(Yonghong),Coward(Ja… Mol Biochem Parasitol 2010-07-22

...FPGS) as a single bifunctional protein. The two activities contribute to the essential pathway of folate biosynthesis an...

Identification and validation of suitable endogenous reference genes for gene e…

Stamova(Boryana S),Apperson(Michelle),Walker… BMC Med Genomics 2009-12-14

...FPGS, FARP1, MAPRE2, PEX16, GINS2, CRY2, CSNK1G2 and A4GALT), 4 commonly employed reference genes (GAPDH, ACTB, B2M and ...

Screening for diabetes, impaired glucose tolerance, and cardiovascular risk in …

White(Bronwyn),Chamberlain(Nick) N Z Med J 2009-08-20

...FPGs is required. Because CVRA uptake was lower in Maori, caution is advised against reliance on CVRA programmes as the ...

Interaction of genes from influx-metabolism-efflux pathway and their influence …

Sharma(Shruti),Das(Mitashree),Kumar(Ashok),M… Pharmacogenet Genomics 2009-03-06

...FPGS, GGH and MDR1 genes to MTX response in RA patients from North India.,RA patients recruited using American College o...

Trends in postpartum diabetes screening and subsequent diabetes and impaired fa…

Ferrara(Assiamira),Peng(Tiffany),Kim(Catheri… Diabetes Care 2009-03-11

...FPGs alone, the 2-h values identify a higher proportion of women with diabetes or pre-diabetes amenable to intervention.

Outcomes of methotrexate therapy for psoriasis and relationship to genetic poly…

Warren(R B),Smith(R L),Campalani(E),Eyre(S),… Br J Dermatol 2009-04-13

...FPGS), gamma-glutamyl hydrolase (GGH), methylenetetrahydrofolate reductase (MTHFR) and 5-aminoimidazole-4-carboxamide ri...

Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of anti…

Stark(Michal),Wichman(Chen),Avivi(Irit),Assa… Blood 2009-06-02

...FPGS activity. We demonstrate that these MTX-resistant cells exhibit impaired splicing of FPGS mRNA based on intron rete...

Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-h…

Fotoohi(Alan Kambiz),Assaraf(Yehuda G),Moshf… Biochem Pharmacol 2009-06-02

...FPGS) activity. This was in contradistinction to the major modality of antifolate resistance of impaired drug transport ...

Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthr…

Sharma(Shruti),Das(Mitashree),Kumar(Ashok),M… Pharmacogenet Genomics 2009-12-23

...FPGS rs1544105, TYMS rs2853539, DHFR rs7387, and ADA rs244076 were identified as putative predictors for MTX response. C...

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