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Expression Profiles of Cytokine mRNAs in the Pleural Fluid Reveal Differences A…

Espósito(Danillo Lucas Alves),Bollela(Valdes… Lung 2016-08-23

...RORC genes, which showed a statistically higher level in TB. All cytokines in the Th17 pattern were induced in TB patien...

A survey of disease connections for CD4+ T cell master genes and their directly…

Li(Wentian),Espinal-Enríquez(Jesús),Simpfend… Comput Biol Chem 2016-09-26

...RORC, BCL6, and FOXP3). We compiled a list of genes functionally interacting (protein-protein interaction, or by acting ...

[Up-regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) of CD4⁺ T…

Wu(Shouzhen),Zhang(Xiaoyan),Zhou(Nan) Xi Bao Yu Fen Zi Mian Yi Xue … 2016-03-07

...RORC and IL-17A, but not with IL-6.,SGK1 was up-regulated in CD4⁺ T cells and was positively correlated with RORC and IL...

Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists.

Fauber(Benjamin P),Gobbi(Alberto),Savy(Pasca… Bioorg Med Chem Lett 2016-05-23

...RORc inverse agonist activity and RORc cellular potencies. These improved N-sulfonyl-tetrahydroquinoline compounds also ...

Inhibitory Effect of a Novel Antirheumatic Drug T-614 on the IL-6-Induced RANKL…

Wei(Yu),Sun(Xiaoxun),Hua(Minhui),Tan(Wenfeng… Biomed Res Int 2016-05-10

...RORc), and MMP-3 mRNA expression were also observed in IL-6-induced RASFs in the presence of T-614 or MTX compared with ...

Elevated Th22 as well as Th17 cells associated with therapeutic outcome and cli…

Wang(Min),Chen(Ping),Jia(Yan),He(Na),Li(Daqi… Oncotarget 2016-05-24

...RORC mRNA expression was examined by RT-PCR. Here, we found that the frequency of Th22 cells was significantly elevated ...

Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic…

Zheng(Jie),van de Veerdonk(Frank L),Crosslan… Eur J Immunol 2016-01-08

...RORC/IL-17/IL-22/IL-10/c-Fos/SOCS3/c-Myc) as likely underlying mechanism. STAT binding to the high affinity sis-inducibl...

Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT…

Yoon(Jeong-Hwan),Sudo(Katsuko),Kuroda(Masahi… Nat Commun 2016-05-09

...Rorc, by acting as a co-activator and co-repressor of STAT3, respectively. Smad2 linker phosphorylated by extracellular ...

SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activa…

Sarkar(Koustav),Sadhukhan(Sanjoy),Han(Seong-… Blood 2016-01-06

...RORC, and CSF2) under TH1-skewing conditions, suggesting a role for WASp in modulating TH1/TH17 plasticity. Notably, pan...

Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17…

Olsson(Roine I),Xue(Yafeng),von Berg(Stefan)… ChemMedChem 2016-09-19

...RORc, RORγ), has been identified as the master regulator of T-helper 17 (TH 17) cell function and development, making it...

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