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Speckle-type POZ protein, SPOP, is involved in the DNA damage response.

Zhang(Dan),Wang(Haibo),Sun(Mianen),Yang(Jun)… Carcinogenesis 2015-02-18

...SPOP have been observed in various tumor types with chromosomal aberrations, indicating a role of SPOP in maintaining ge...

Endometrial cancer-associated mutants of SPOP are defective in regulating estro…

Zhang(P),Gao(K),Jin(X),Ma(J),Peng(J),Wumaier… Cell Death Dis 2015-11-30

...SPOP (5.7-10%). However, how SPOP mutations contribute to endometrial cancer remains unknown. Here, we identified estrog...

SPOP Mutations or ERG Rearrangements Result in Enhanced Levels of ERG to Promot…

Duan(Shanshan),Pagano(Michele) Mol Cell 2015-12-22

...SPOP prevent CRL3(SPOP)-dependent degradation of ERG in prostate cancer cells.

Pelvic organ prolapse and incontinence 15-23 years after first delivery: a cros…

Volløyhaug(I),Mørkved(S),Salvesen(Ø),Salvese… BJOG 2015-08-11

...sPOP), urinary incontinence or surgery (UI) and fecal incontinence or surgery (FI).,When caesarean delivery was compared...

Reprint of: The prostate cancer genome: Perspectives and potential.

Barbieri(Christopher E),Tomlins(Scott A) Urol Oncol 2015-12-14

...SPOP. Accumulating data suggests that prostate cancer can be subdivided based on a molecular profile of these genetic al...

Mutation detection in formalin-fixed prostate cancer biopsies taken at the time…

Manson-Bahr(David),Ball(Richard),Gundem(Gune… J Clin Pathol 2015-05-20

...SPOP, TP53, ATM, MEN1, NBPF10, NCOR2, PIK3CB and MAP2K5 (MEK5) genes.,Using the methods presented here, NGS technologies...

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress…

Gan(Wenjian),Dai(Xiangpeng),Lunardi(Andrea),… Mol Cell 2015-12-21

...SPOP-mediated destruction, whereas prostate cancer-associated SPOP mutants are also deficient in promoting ERG ubiquitin...

Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Media…

An(Jian),Ren(Shancheng),Murphy(Stephen J),Da… Mol Cell 2015-12-21

...SPOP mutations abrogate the SPOP-mediated degradation function on the ERG oncoprotein. Conversely, the majority of TMPRS...

Molecular foundations for personalized therapy in prostate cancer.

Fisher(Kurt W),Montironi(Rodolfo),Lopez Belt… Curr Drug Targets 2015-10-28

...SPOP mutations. By reviewing the associations between the morphologic features and the molecular genetics of prostate ca...

Tumor suppressor SPOP mediates the proteasomal degradation of progesterone rece…

Gao(Kun),Jin(Xiaofeng),Tang(Yan),Ma(Jian),Pe… Am J Cancer Res 2015-12-22

...SPOP. SPOP interacts with PR in vivo and targets PR for ubiquitin-dependent proteasomal degradation. Moreover, SPOP supp...

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