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The GRP94/LMAN1-MCFD2 axis controls secretion of chemosensory proteins and en...

Liu(A),Li(DZ),Yang(RN),Yang(MJ),Abdelnabby... Pest Manag Sci 2026-08-18

...MCFD2 axis that governs the folding and secretion of NlCSP1. NlGRP94 and NlGRP78 act as chaperones, and NlLMAN1-NlMCFD2 ...

Incidental Finding of Combined Factor V and VIII Deficiency in the Setting of...

Luzarraga(JL),Purow(JI),Berkman(A) Cureus 2025-09-00

...MCFD2, leading to combined F5 and F8 deficiency. Rarely, it can be of digenic inheritance with separate defects in F5 an...

Global analyses of Chromosome 17 and 18 genes of lung telocytes compared with...

Wang(Jian),Ye(Ling),Jin(Meiling),Wang(Xian... Biol Direct 2016-02-08

...MCFD2 and down-regulated E4F1 and PDCD2 had an association with tissue homeostasis for TCs. Over-expressed Dpysl3 may pr...

Unveiling the unfolding pathway of F5F8D disorder-associated D81H/V100D mutan...

Hamza(Adel),Wei(Ning-Ning),Johnson-Scalise... J Biomol Struct Dyn 2016-04-23

...MCFD2-LMAN1 complex. Here, we have investigated the solution conformations of the MCFD2((D81H,V100D)) protein mutant thr...

Combined deficiency of coagulation factors V and VIII: an update.

Zheng(Chunlei),Zhang(Bin) Semin Thromb Hemost 2014-03-20

...MCFD2 as causative genes for this disorder, revealing a previously unknown intracellular transport pathway shared by the...

Structural basis for disparate sugar-binding specificities in the homologous ...

Satoh(Tadashi),Suzuki(Kousuke),Yamaguchi(T... PLoS One 2014-10-20

...MCFD2 and the α1,2 mannotriose which corresponds to the trisaccharide of the D1 arm of high-mannose-type glycans. ERGIC-...

Successful percutaneous coronary intervention in a patient with combined defi...

Patel(A J),Liu(H-H),Lager(R A),Malkovska(V... Haemophilia 2014-01-22

...MCFD2 genes. Mutations in LMAN1 was confirmed by molecular cloning of the PCR product and resequencing of the resulting ...

Regulation of Mac-2BP secretion is mediated by its N-glycan binding to ERGIC-53.

Chen(Yang),Hojo(Sanae),Matsumoto(Naoki),Ya... Glycobiology 2014-01-02

...MCFD2 is involved in the secretion of Mac-2BP. These observations reveal a distinct role for the N-glycan binding of ERG...

Multiple coagulation factor deficiency protein 2 contains the ability to supp...

Liu(Huan),Zhao(Bo),Chen(Yongchang),You(Dew... FASEB J 2013-12-16

...MCFD2) are a cause of factor V and factor VIII combined deficiency type 2 (F5F8D). MCFD2 was also suggested to play an i...

Structural characterization of carbohydrate binding by LMAN1 protein provides...

Zheng(Chunlei),Page(Richard C),Das(Vaijaya... J Biol Chem 2013-09-27

...MCFD2, LMAN1 transports coagulation factors V (FV) and VIII (FVIII). Mutations in LMAN1 or MCFD2 cause the genetic bleed...

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