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The role of Notch signalling and its crosstalk with oestrogen receptor signalli…

Azadova(A),Isayev(O),Marco(A),Brooke(GN) Cancer Metastasis Rev 2026-03-27

...Notch1 and 4 promote tumour aggressiveness, whereas Notch2 often exhibits tumour-suppressive roles. In ERα-positive BCa,...

Ginsenoside Rb1 downregulates proinflammatory cytokines expression via the Tlr2…

Li(Y),Jia(C),Hu(J),Tang(C),Zheng(T),Wang(J),… Biochem Biophys Res Commun 2026-05-28

...Notch1, and Hes1 in the myocardial tissues of EAM mice, with IL-6 showing the most significant increase (P < 0.001). Gin...

Renoprotective effects of DAPT against zymosan-induced acute kidney injury and …

Safwat(MH),Abd El-Aleam(RH),Rashad(E),El-Tan… Eur J Pharmacol 2026-04-15

...Notch1/Notch intracellular domain, and hairy and enhancer of split 1. DAPT lowered p21Waf1/Cip1 and p16INK4a along with ...

Molecular subtyping-guided precision therapy for ESCC: biomarker-driven strateg…

Lv(H),Zhao(W),Wang(SQ),Chen(XB) Clin Transl Oncol 2026-09-00

...NOTCH1 mutations) and emerging therapies targeting driver genes and the metabolic microenvironment. Translating subtypin...

Targeting notch signaling to restore neural development and behavior in mouse m…

Hanno(Y),Nakanishi(M),Takase(A),Nomura(J),Ta… Nat Commun 2026-03-30

...Notch1/2 genes in ASD models restores the loss of VIP-INs, normalizes maladaptive excitatory and inhibitory balance, and...

Cordycepin alleviates ischaemic brain injury by suppressing microglia-induced n…

Li(X),Zhan(GF),Zhang(X),Zhao(YL),Mao(M),Xia(… Br J Pharmacol 2026-07-00

...Notch1 intracellular domain (NICD) and subsequently blocked the activation of the Notch1 signalling pathway in microglia...

NOTCH4 as a driver of epithelial-mesenchymal transition, angiogenesis, and stro…

Koh(YW),Han(JH),Haam(S),Lee(HW) Transl Lung Cancer Res 2026-03-23

...NOTCH1 and NOTCH3. Gene set enrichment analysis (GSEA) and deconvolution-based TME analyses (xCell, ESTIMATE, and MCP-co...

HDAC3 Regulates Transcriptional Networks Governing Decidualization.

Nguyen(LTK),Tran(DN),Nahar(S),Kim(TH),Jeong(… FASEB J 2026-04-30

...NOTCH1-HEY1, and oxidative stress-induced senescence signaling, implicating dysregulation of cytoskeletal remodeling, ce...

Orai1 Facilitates Angiogenesis After Myocardial Infarction Through Notch1 Signa…

Galeano-Otero(I),Dominguez-Liste(B),Asprón(C… Arterioscler Thromb Vasc Biol 2026-06-00

...Notch1-related proangiogenic proteins. Furthermore, IL (interleukin)-17A mimicked ST-segment-elevation MI serum, inducin...

NOTCH1 acts as a tumor suppressor that induces early differentiation in head an…

Huang(C),Moorthy(S),Li(Q),Ahmed(KM),Saab(K),… JCI Insight 2026-06-08

...NOTCH1, with broader implications in other squamous carcinomas with NOTCH1 mutations.

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