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PMID: 1068479 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Structural studies on protein products of murine chromosome 17: partial amino acid sequence of an H-2Kb molecule.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 10 ·1976-10-00 ·Pages 3661-5

Capra JD, Vitetta ES, Klapper DG, Uhr JW, Klein J

Abstract

By use of single internal radiolabels, 17 of the NH2-terminal 27 amino acids of the murine H-2Kb molecule have been assigned. When the amino acid sequence is compared to that of the murine H-2Kk molecule, there is a minimum of six amino acid differences in 19 positions. This high degree of structural diversity confirms, at the level of amino acid sequence, the known polymorphism of the murine H-2 complex. Significant primary str-ctural homology is evident when the murine H-2Kk and H-2Kb sequences are compared to the recently reported partial amino acid sequences of human transplantation antigens. There is modest homology with beta2-mictoglobulin and immunoglobulins, but the available sequence information is insufficient for a satisfactory evaluation of its significance.

MeSH Terms
Alleles Amino Acid Sequence Animals HLA Antigens Histocompatibility Antigens/isolation & purification Mice Polymorphism, Genetic Spleen
Chemicals
HLA Antigens Histocompatibility Antigens
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Capra J D
Vitetta E S
Klapper D G
Uhr J W
Klein J
References (30)
30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.10.3661
Published
1976-10-00
Pages
3661-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431178
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.10.3661 PMC Full Text View journal details
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