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PMID: 1104574 Published · ppublish English Journal Article

Translocation of the tetracycline resistance determinant from R100-1 to the Escherichia coli K-12 chromosome.

Journal of bacteriology ·Vol. 124 ·No. 3 ·1975-12-00 ·Pages 1153-8

Foster TJ, Howe TG, Richmond KM

Abstract

Pairs of normally incompatible derivatives of R100-1 (one ChlS TetR, the other ChilR TetS) were forced to coexist in a recA host by selection for ChlR TetR cells. After many generations stable derivatives were isolated. The analysis of none independent stabilization experiments showed that in each case TetR was translocated from the plasmid to the chromosome of the host. No evidence for the joint integration of other plasmid genes (those controlling transfer, antibiotic resistance, incompatibility, or origin of transfer replication) was obtained. One of the chromosomal TetR determinants was mapped close to metE.

MeSH Terms
Chloramphenicol/pharmacology Chromosome Mapping Chromosomes, Bacterial Conjugation, Genetic Drug Resistance, Microbial Escherichia coli/drug effects Mutation R Factors Tetracycline/pharmacology Transduction, Genetic
Chemicals
Chloramphenicol Tetracycline
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Foster T J
Howe T G
Richmond K M
References (32)
32 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.124.3.1153-1158.1975
Published
1975-12-00
Pages
1153-8
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC236021
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.124.3.1153-1158.1975 PMC Full Text View journal details
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