Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters.

Journal of bacteriology ·Vol. 183 ·No. 4 ·2001-02-00 ·Pages 1455-8

Nishino K, Yamaguchi A

Abstract

Overexpression of evgA, a response regulator of a two-component system, increased multidrug efflux in Escherichia coli. Since overexpression of the emrKY operon, which is controlled by evgAS, could account only for deoxycholate resistance, the evgAS locus apparently controls expression of at least one other multidrug efflux operon.

MeSH Terms

ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics,metabolism Amino Acid Sequence Bacterial Proteins/biosynthesis Biological Transport Doxorubicin/metabolism Drug Resistance, Microbial Drug Resistance, Multiple/genetics Escherichia coli Escherichia coli Proteins Gene Expression Regulation, Bacterial Microbial Sensitivity Tests Molecular Sequence Data Rhodamines/metabolism Signal Transduction Transcription Factors/biosynthesis

Chemicals

ATP Binding Cassette Transporter, Subfamily B, Member 1 Bacterial Proteins BvgA protein, Bacteria Escherichia coli Proteins EvgA protein, E coli Rhodamines Transcription Factors rhodamine 6G Doxorubicin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Nishino K

Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan.

Yamaguchi A

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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/JB.183.4.1455-1458.2001

Published

2001-02-00

Pages

1455-8

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC95021

Subset

External Links

PubMed source DOI: 10.1128/JB.183.4.1455-1458.2001 PMC Full Text View journal details

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Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters.

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