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PMID: 11179208 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The Spemann organizer and embryonic head induction.

The EMBO journal ·Vol. 20 ·No. 4 ·2001-02-15 ·Pages 631-7

Niehrs C

Abstract

暂无摘要

MeSH Terms
Animals Bone Morphogenetic Proteins/antagonists & inhibitors,physiology Embryonic Induction/physiology Head/embryology Humans Proto-Oncogene Proteins/antagonists & inhibitors,physiology Wnt Proteins Zebrafish Proteins
Chemicals
Bone Morphogenetic Proteins Proto-Oncogene Proteins Wnt Proteins Zebrafish Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Niehrs C
Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
References (76)
76 references, click to expand
  1. Mesodermal patterning by a gradient of the vertebrate homeobox gene goosecoid.
    Science. 1994 Feb 11;263(5148):817-20 PMID: 7905664
  2. Molecular mechanisms of tissue determination and pattern formation in amphibian embryos.
    Naturwissenschaften. 1995 Mar;82(3):123-34 PMID: 7723850
  3. Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1.
    EMBO J. 1995 Dec 15;14(24):6268-79 PMID: 8557046
  4. A common plan for dorsoventral patterning in Bilateria.
    Nature. 1996 Mar 7;380(6569):37-40 PMID: 8598900
  5. A Xenopus gene, Xbr-1, defines a novel class of homeobox genes and is expressed in the dorsal ciliary margin of the eye.
    Dev Biol. 1996 Feb 25;174(1):104-14 PMID: 8626010
  6. Direct and long-range action of a DPP morphogen gradient.
    Cell. 1996 May 3;85(3):357-68 PMID: 8616891
  7. Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing.
    Nature. 1996 May 30;381(6581):387-93 PMID: 8632795
  8. Regulation of dorsal-ventral patterning: the ventralizing effects of the novel Xenopus homeobox gene Vox.
    Development. 1996 Jun;122(6):1711-21 PMID: 8674411
  9. Bone morphogenetic proteins: multifunctional regulators of vertebrate development.
    Genes Dev. 1996 Jul 1;10(13):1580-94 PMID: 8682290
  10. A novel homeobox gene PV.1 mediates induction of ventral mesoderm in Xenopus embryos.
    Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6415-20 PMID: 8692829
  11. Xom: a Xenopus homeobox gene that mediates the early effects of BMP-4.
    Development. 1996 Aug;122(8):2385-94 PMID: 8756284
  12. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer.
    Nature. 1996 Aug 15;382(6592):595-601 PMID: 8757128
  13. Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.
    Cell. 1996 Aug 23;86(4):589-98 PMID: 8752213
  14. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.
    Cell. 1996 Aug 23;86(4):599-606 PMID: 8752214
  15. The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor.
    Cell. 1996 Aug 23;86(4):607-17 PMID: 8752215
  16. Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction.
    Development. 1999 Jan;126(2):229-40 PMID: 9847237
  17. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals.
    Nature. 1999 Feb 25;397(6721):707-10 PMID: 10067895
  18. Transcriptional regulation of Xvent homeobox genes.
    Mech Dev. 1999 Mar;81(1-2):139-49 PMID: 10330491
  19. Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos.
    Genes Dev. 1999 Jun 1;13(11):1486-99 PMID: 10364164
  20. Systematic determination of genetic network architecture.
    Nat Genet. 1999 Jul;22(3):281-5 PMID: 10391217
  21. Regulation of dorsal gene expression in Xenopus by the ventralizing homeodomain gene Vox.
    Dev Biol. 1999 Jul 15;211(2):293-305 PMID: 10395789
  22. Head in the WNT: the molecular nature of Spemann's head organizer.
    Trends Genet. 1999 Aug;15(8):314-9 PMID: 10431193
  23. Activin as a morphogen in Xenopus mesoderm induction.
    Semin Cell Dev Biol. 1999 Jun;10(3):311-7 PMID: 10441545
  24. A gradient of BMP activity specifies dorsal-ventral fates in early Xenopus embryos.
    Semin Cell Dev Biol. 1999 Jun;10(3):319-26 PMID: 10441546
  25. Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development.
    Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12141-5 PMID: 8618860
  26. Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation.
    Mol Cell. 1999 Sep;4(3):287-98 PMID: 10518210
  27. Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
    Nature. 1999 Sep 30;401(6752):480-5 PMID: 10519551
  28. DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.
    Development. 1992 Jun;115(2):639-47 PMID: 1425343
  29. Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.
    Genes Dev. 1993 Jan;7(1):13-28 PMID: 8422982
  30. The homeobox gene goosecoid controls cell migration in Xenopus embryos.
    Cell. 1993 Feb 26;72(4):491-503 PMID: 8095000
  31. Spemann's organizer: models and molecules.
    Mech Dev. 1993 May;41(2-3):73-89 PMID: 8518194
  32. Mesoderm-inducing factors in early vertebrate development.
    EMBO J. 1993 Dec;12(12):4463-70 PMID: 8223456
  33. Wnt-3a regulates somite and tailbud formation in the mouse embryo.
    Genes Dev. 1994 Jan;8(2):174-89 PMID: 8299937
  34. Conservation of dorsal-ventral patterning in arthropods and chordates.
    Curr Opin Genet Dev. 1996 Aug;6(4):424-31 PMID: 8791529
  35. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.
    Nature. 1996 Oct 31;383(6603):832-6 PMID: 8893010
  36. The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controlling [correction of controling] dorsoventral patterning of Xenopus mesoderm.
    Development. 1996 Oct;122(10):3045-53 PMID: 8898218
  37. Signalling by TGF-beta family members: short-range effects of Xnr-2 and BMP-4 contrast with the long-range effects of activin.
    Curr Biol. 1996 Nov 1;6(11):1468-75 PMID: 8939607
  38. The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation.
    Mech Dev. 1997 Jan;61(1-2):127-40 PMID: 9076683
  39. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer.
    Cell. 1997 Mar 21;88(6):747-56 PMID: 9118218
  40. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8.
    Cell. 1997 Mar 21;88(6):757-66 PMID: 9118219
  41. Fish are like flies are like frogs: conservation of dorsal-ventral patterning mechanisms.
    Bioessays. 1997 Apr;19(4):281-4 PMID: 9136625
  42. Short historical survey of pattern formation in the endo-mesoderm and the neural anlage in the vertebrates: the role of vertical and planar inductive actions.
    Cell Mol Life Sci. 1997 Apr;53(4):305-18 PMID: 9137623
  43. Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus.
    Development. 1997 Jun;124(12):2325-34 PMID: 9199359
  44. Morphogens and pattern formation.
    Bioessays. 1997 Aug;19(8):721-9 PMID: 9264255
  45. Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4.
    Development. 1997 Aug;124(16):3037-44 PMID: 9272945
  46. Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus.
    Nature. 1997 Oct 2;389(6650):517-9 PMID: 9333244
  47. Formation and function of Spemann's organizer.
    Annu Rev Cell Dev Biol. 1997;13:611-67 PMID: 9442883
  48. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.
    Nature. 1998 Jan 22;391(6665):357-62 PMID: 9450748
  49. Establishment of a BMP-4 morphogen gradient by long-range inhibition.
    Dev Biol. 1998 Feb 1;194(1):12-7 PMID: 9473328
  50. Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm.
    Development. 1998 Apr;125(8):1447-56 PMID: 9502725
  51. Xvent-1 mediates BMP-4-induced suppression of the dorsal-lip-specific early response gene XFD-1' in Xenopus embryos.
    EMBO J. 1998 Apr 15;17(8):2298-307 PMID: 9545242
  52. Neural induction in whole chick embryo cultures by FGF.
    Dev Biol. 1998 Jul 1;199(1):42-54 PMID: 9676191
  53. Gene-expression screens in vertebrate embryos: more than meets the eye.
    Genes Funct. 1997 Nov;1(4):229-31 PMID: 9678899
  54. BMPs, Smads and metalloproteases: extracellular and intracellular modes of negative regulation.
    Curr Opin Genet Dev. 1998 Aug;8(4):443-9 PMID: 9729721
  55. TGF-beta signal transduction.
    Annu Rev Biochem. 1998;67:753-91 PMID: 9759503
  56. Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning.
    Mech Dev. 1998 Oct;77(2):95-141 PMID: 9831640
  57. Cluster analysis and display of genome-wide expression patterns.
    Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863-8 PMID: 9843981
  58. The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in Spemann's organizer.
    EMBO J. 1999 Nov 1;18(21):6062-72 PMID: 10545117
  59. Synexpression groups in eukaryotes.
    Nature. 1999 Dec 2;402(6761):483-7 PMID: 10591207
  60. DNA-binding specificity and embryological function of Xom (Xvent-2).
    Dev Biol. 1999 Dec 15;216(2):442-56 PMID: 10642784
  61. Nodal signalling in vertebrate development.
    Nature. 2000 Jan 27;403(6768):385-9 PMID: 10667782
  62. The organizer factors Chordin and Noggin are required for mouse forebrain development.
    Nature. 2000 Feb 10;403(6770):658-61 PMID: 10688202
  63. An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryo.
    Curr Biol. 2000 Apr 20;10(8):421-9 PMID: 10801412
  64. The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways.
    Development. 2000 Jun;127(11):2333-45 PMID: 10804176
  65. Genomics, gene expression and DNA arrays.
    Nature. 2000 Jun 15;405(6788):827-36 PMID: 10866209
  66. Anterior endoderm and head induction in early vertebrate embryos.
    Cell Tissue Res. 2000 May;300(2):207-17 PMID: 10867817
  67. Initiation of neural induction by FGF signalling before gastrulation.
    Nature. 2000 Jul 6;406(6791):74-8 PMID: 10894544
  68. Patterning the early zebrafish by the opposing actions of bozozok and vox/vent.
    Dev Biol. 2000 Aug 15;224(2):275-85 PMID: 10926766
  69. The homeodomain transcription factor Xvent-2 mediates autocatalytic regulation of BMP-4 expression in Xenopus embryos.
    J Biol Chem. 2000 Nov 3;275(44):34365-74 PMID: 10938274
  70. Repressor activity of Headless/Tcf3 is essential for vertebrate head formation.
    Nature. 2000 Oct 19;407(6806):913-6 PMID: 11057671
  71. The establishment of Spemann's organizer and patterning of the vertebrate embryo.
    Nat Rev Genet. 2000 Dec;1(3):171-81 PMID: 11252746
  72. Organizer-specific homeobox genes in Xenopus laevis embryos.
    Science. 1991 Jul 12;253(5016):194-6 PMID: 1677215
  73. Bone morphogenetic protein 4 (BMP-4), a member of the TGF-beta family, in early embryos of Xenopus laevis: analysis of mesoderm inducing activity.
    Mech Dev. 1991 Mar;33(3):191-9 PMID: 1863557
  74. Ectopic expression of a homeobox gene changes cell fate in Xenopus embryos in a position-specific manner.
    EMBO J. 1991 Dec;10(12):3621-9 PMID: 1682146
  75. Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid.
    Cell. 1991 Dec 20;67(6):1111-20 PMID: 1684739
  76. Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development.
    Development. 1992 Jun;115(2):573-85 PMID: 1425340
Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
DOI
10.1093/emboj/20.4.631
Published
2001-02-15
Pages
631-7
Language
English
Region
England
NLM ID
8208664
PMCID
PMC145408
Subset
IM
External Links
PubMed source DOI: 10.1093/emboj/20.4.631 PMC Full Text View journal details
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