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PMID: 11222580 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The pleiotropic two-component regulatory system PhoP-PhoQ.

Journal of bacteriology ·Vol. 183 ·No. 6 ·2001-03-00 ·Pages 1835-42

Groisman EA

Abstract

暂无摘要

MeSH Terms
Animals Bacterial Proteins/genetics,metabolism Gene Expression Regulation, Bacterial Humans Hydrogen-Ion Concentration Magnesium/metabolism Mice Promoter Regions, Genetic Salmonella/genetics,metabolism,pathogenicity Signal Transduction Transcription, Genetic Virulence
Chemicals
Bacterial Proteins PhoQ protein, Bacteria PhoP protein, Bacteria Magnesium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Groisman E A
Howard Hughes Medical Institute, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110-1093, USA. [email protected]
References (81)
81 references, click to expand
  1. Function of conserved histidine-243 in phosphatase activity of EnvZ, the sensor for porin osmoregulation in Escherichia coli.
    J Bacteriol. 1997 Jun;179(11):3729-35 PMID: 9171423
  2. Fluorescence-based isolation of bacterial genes expressed within host cells.
    Science. 1997 Sep 26;277(5334):2007-11 PMID: 9302299
  3. The Salmonella selC locus contains a pathogenicity island mediating intramacrophage survival.
    EMBO J. 1997 Sep 1;16(17):5376-85 PMID: 9311997
  4. Control of virulence gene expression by plant calcium in the phytopathogen Erwinia carotovora.
    Mol Microbiol. 1997 Sep;25(5):831-8 PMID: 9364909
  5. Regulation of polymyxin resistance and adaptation to low-Mg2+ environments.
    J Bacteriol. 1997 Nov;179(22):7040-5 PMID: 9371451
  6. The ins and outs of virulence gene expression: Mg2+ as a regulatory signal.
    Bioessays. 1998 Jan;20(1):96-101 PMID: 9504051
  7. Molecular characterization of the PmrA regulon.
    J Biol Chem. 1999 Sep 17;274(38):27185-90 PMID: 10480935
  8. A PhoP-repressed gene promotes Salmonella typhimurium invasion of epithelial cells.
    J Bacteriol. 1993 Jul;175(14):4475-84 PMID: 8392513
  9. Salmonella stimulate macrophage macropinocytosis and persist within spacious phagosomes.
    J Exp Med. 1994 Feb 1;179(2):601-8 PMID: 8294870
  10. Further characterization of the PhoP regulon: identification of new PhoP-activated virulence loci.
    Infect Immun. 1994 Nov;62(11):5095-101 PMID: 7927792
  11. Transcriptional autoregulation of the Salmonella typhimurium phoPQ operon.
    J Bacteriol. 1995 Aug;177(15):4364-71 PMID: 7543474
  12. PhoP/PhoQ transcriptional repression of Salmonella typhimurium invasion genes: evidence for a role in protein secretion.
    Mol Microbiol. 1995 Jul;17(1):169-81 PMID: 7476203
  13. The phoP locus influences processing and presentation of Salmonella typhimurium antigens by activated macrophages.
    Mol Microbiol. 1995 May;16(3):465-76 PMID: 7565107
  14. Mg2+ as an extracellular signal: environmental regulation of Salmonella virulence.
    Cell. 1996 Jan 12;84(1):165-74 PMID: 8548821
  15. phoP/phoQ-deleted Salmonella typhi (Ty800) is a safe and immunogenic single-dose typhoid fever vaccine in volunteers.
    J Infect Dis. 1996 Jun;173(6):1408-14 PMID: 8648213
  16. The signal-transduction network for Pho regulation in Bacillus subtilis.
    Mol Microbiol. 1996 Mar;19(5):933-9 PMID: 8830274
  17. PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance.
    Mol Microbiol. 1998 Mar;27(6):1171-82 PMID: 9570402
  18. A low pH-inducible, PhoPQ-dependent acid tolerance response protects Salmonella typhimurium against inorganic acid stress.
    J Bacteriol. 1998 May;180(9):2409-17 PMID: 9573193
  19. Control of peptidoglycan synthesis in vancomycin-resistant enterococci: D,D-peptidases and D,D-carboxypeptidases.
    Cell Mol Life Sci. 1998 Apr;54(4):325-31 PMID: 9614968
  20. Microbial magnesium transport: unusual transporters searching for identity.
    Mol Microbiol. 1998 Apr;28(2):217-26 PMID: 9622348
  21. Magnesium and the role of MgtC in growth of Salmonella typhimurium.
    Infect Immun. 1998 Aug;66(8):3802-9 PMID: 9673265
  22. A regulatory cascade involving AarG, a putative sensor kinase, controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii.
    Mol Microbiol. 1998 Jun;28(6):1345-53 PMID: 9680222
  23. Magnesium transport in Salmonella typhimurium: regulation of mgtA and mgtCB during invasion of epithelial and macrophage cells.
    Microbiology. 1998 Jul;144 ( Pt 7):1835-43 PMID: 9695916
  24. Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages.
    Mol Microbiol. 1998 Oct;30(1):163-74 PMID: 9786193
  25. Macrophage-dependent induction of the Salmonella pathogenicity island 2 type III secretion system and its role in intracellular survival.
    Mol Microbiol. 1998 Oct;30(1):175-88 PMID: 9786194
  26. Lipid A acylation and bacterial resistance against vertebrate antimicrobial peptides.
    Cell. 1998 Oct 16;95(2):189-98 PMID: 9790526
  27. Coordinate intracellular expression of Salmonella genes induced during infection.
    J Bacteriol. 1999 Feb;181(3):799-807 PMID: 9922242
  28. PhoP-PhoQ-regulated loci are required for enhanced bile resistance in Salmonella spp.
    Infect Immun. 1999 Apr;67(4):1614-22 PMID: 10084994
  29. A periplasmic D-alanyl-D-alanine dipeptidase in the gram-negative bacterium Salmonella enterica.
    J Bacteriol. 1999 Apr;181(7):2158-65 PMID: 10094694
  30. Environmental regulation of Salmonella pathogenicity island 2 gene expression.
    Mol Microbiol. 1999 Mar;31(6):1759-73 PMID: 10209748
  31. Animal antimicrobial peptides: an overview.
    Biopolymers. 1998;47(6):415-33 PMID: 10333735
  32. Mode of action of linear amphipathic alpha-helical antimicrobial peptides.
    Biopolymers. 1998;47(6):451-63 PMID: 10333737
  33. Molecular characterization of the PhoP-PhoQ two-component system in Escherichia coli K-12: identification of extracellular Mg2+-responsive promoters.
    J Bacteriol. 1999 Sep;181(17):5516-20 PMID: 10464230
  34. PhoP-PhoQ homologues in Pseudomonas aeruginosa regulate expression of the outer-membrane protein OprH and polymyxin B resistance.
    Mol Microbiol. 1999 Oct;34(2):305-16 PMID: 10564474
  35. Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa.
    Science. 1999 Nov 19;286(5444):1561-5 PMID: 10567263
  36. A two-component regulatory system, pehR-pehS, controls endopolygalacturonase production and virulence in the plant pathogen Erwinia carotovora subsp. carotovora.
    Mol Plant Microbe Interact. 2000 Apr;13(4):447-55 PMID: 10755308
  37. A parallel intraphagosomal survival strategy shared by mycobacterium tuberculosis and Salmonella enterica.
    Mol Microbiol. 2000 Mar;35(6):1375-82 PMID: 10760138
  38. A small protein that mediates the activation of a two-component system by another two-component system.
    EMBO J. 2000 Apr 17;19(8):1861-72 PMID: 10775270
  39. The response regulator PhoP is important for survival under conditions of macrophage-induced stress and virulence in Yersinia pestis.
    Infect Immun. 2000 Jun;68(6):3419-25 PMID: 10816493
  40. Phosphorylated PmrA interacts with the promoter region of ugd in Salmonella enterica serovar typhimurium.
    J Bacteriol. 2000 Jul;182(13):3874-6 PMID: 10851011
  41. A PhoP-regulated outer membrane protease of Salmonella enterica serovar typhimurium promotes resistance to alpha-helical antimicrobial peptides.
    J Bacteriol. 2000 Jul;182(14):4077-86 PMID: 10869088
  42. Acetyl phosphate-dependent activation of a mutant PhoP response regulator that functions independently of its cognate sensor kinase.
    J Mol Biol. 2000 Jul 7;300(2):291-305 PMID: 10873466
  43. The phosphatase activity is the target for Mg2+ regulation of the sensor protein PhoQ in Salmonella.
    J Biol Chem. 2000 Jul 28;275(30):22948-54 PMID: 10807931
  44. Constitutively expressed phoP inhibits mouse-virulence of Salmonella typhimurium in an Spv-dependent manner.
    Microbiol Immunol. 2000;44(6):447-54 PMID: 10941927
  45. Role of Pseudomonas aeruginosa PhoP-phoQ in resistance to antimicrobial cationic peptides and aminoglycosides.
    Microbiology. 2000 Oct;146 ( Pt 10):2543-54 PMID: 11021929
  46. Genetic and functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar typhimurium.
    Infect Immun. 2000 Nov;68(11):6139-46 PMID: 11035717
  47. A signal transduction system that responds to extracellular iron.
    Cell. 2000 Sep 29;103(1):113-25 PMID: 11051552
  48. Transfer of palmitate from phospholipids to lipid A in outer membranes of gram-negative bacteria.
    EMBO J. 2000 Oct 2;19(19):5071-80 PMID: 11013210
  49. The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri.
    Cell Microbiol. 2000 Dec;2(6):443-52 PMID: 11207599
  50. Regulation of nonspecific acid phosphatase in Salmonella: phoN and phoP genes.
    J Bacteriol. 1979 Apr;138(1):155-61 PMID: 374361
  51. Lipid A and resistance of Salmonella typhimurium to antimicrobial granule proteins of human neutrophil granulocytes.
    Infect Immun. 1984 Mar;43(3):834-8 PMID: 6199303
  52. Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent.
    Proc Natl Acad Sci U S A. 1986 Jul;83(14):5189-93 PMID: 3523484
  53. Lipopolysaccharide structure determines ionic and hydrophobic binding of a cationic antimicrobial neutrophil granule protein.
    Infect Immun. 1988 Jun;56(6):1589-92 PMID: 3286500
  54. A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells.
    Science. 1989 Feb 24;243(4894 Pt 1):1059-62 PMID: 2646710
  55. A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence.
    Proc Natl Acad Sci U S A. 1989 Jul;86(13):5054-8 PMID: 2544889
  56. Virulence and vaccine potential of phoP mutants of Salmonella typhimurium.
    Microb Pathog. 1989 Jun;6(6):433-43 PMID: 2671582
  57. Salmonella typhimurium phoP virulence gene is a transcriptional regulator.
    Proc Natl Acad Sci U S A. 1989 Sep;86(18):7077-81 PMID: 2674945
  58. Adaptive acidification tolerance response of Salmonella typhimurium.
    J Bacteriol. 1990 Feb;172(2):771-8 PMID: 2404956
  59. Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages.
    J Bacteriol. 1990 May;172(5):2485-90 PMID: 2185222
  60. Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium.
    Infect Immun. 1990 Nov;58(11):3706-10 PMID: 2172166
  61. The mgtB Mg2+ transport locus of Salmonella typhimurium encodes a P-type ATPase.
    J Biol Chem. 1991 Jan 15;266(2):815-23 PMID: 1824701
  62. Growth regulation of a Salmonella plasmid gene essential for virulence.
    J Bacteriol. 1991 Nov;173(21):6783-9 PMID: 1938884
  63. Molecular genetic analysis of the Escherichia coli phoP locus.
    J Bacteriol. 1992 Jan;174(2):486-91 PMID: 1530848
  64. Horizontal transfer of a phosphatase gene as evidence for mosaic structure of the Salmonella genome.
    EMBO J. 1992 Apr;11(4):1309-16 PMID: 1339343
  65. Salmonella typhimurium activates virulence gene transcription within acidified macrophage phagosomes.
    Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10079-83 PMID: 1438196
  66. Resistance to host antimicrobial peptides is necessary for Salmonella virulence.
    Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11939-43 PMID: 1465423
  67. Characterization of the micro-environment of Salmonella typhimurium-containing vacuoles within MDCK epithelial cells.
    Mol Microbiol. 1992 Nov;6(22):3289-97 PMID: 1484485
  68. Spontaneous pmrA mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence.
    J Bacteriol. 1993 Jul;175(13):4154-64 PMID: 8391535
  69. Identification of a pathogenicity island required for Salmonella survival in host cells.
    Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7800-4 PMID: 8755556
  70. Molecular basis of the magnesium deprivation response in Salmonella typhimurium: identification of PhoP-regulated genes.
    J Bacteriol. 1996 Sep;178(17):5092-9 PMID: 8752324
  71. Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP.
    J Bacteriol. 1996 Nov;178(21):6369-73 PMID: 8892844
  72. Signal detection by the PhoQ sensor-transmitter. Characterization of the sensor domain and a response-impaired mutant that identifies ligand-binding determinants.
    J Biol Chem. 1996 Oct 25;271(43):26630-6 PMID: 8900137
  73. Co-ordinate regulation of Salmonella typhimurium invasion genes by environmental and regulatory factors is mediated by control of hilA expression.
    Mol Microbiol. 1996 Nov;22(4):703-14 PMID: 8951817
  74. Two-component regulatory systems can interact to process multiple environmental signals.
    J Bacteriol. 1996 Dec;178(23):6796-801 PMID: 8955299
  75. PhoP-PhoQ activates transcription of pmrAB, encoding a two-component regulatory system involved in Salmonella typhimurium antimicrobial peptide resistance.
    J Bacteriol. 1996 Dec;178(23):6857-64 PMID: 8955307
  76. Shigella flexneri is trapped in polymorphonuclear leukocyte vacuoles and efficiently killed.
    Infect Immun. 1997 Jan;65(1):110-5 PMID: 8975899
  77. Characterization of the bacterial sensor protein PhoQ. Evidence for distinct binding sites for Mg2+ and Ca2+.
    J Biol Chem. 1997 Jan 17;272(3):1440-3 PMID: 8999810
  78. Bacterial infection as assessed by in vivo gene expression.
    Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):934-9 PMID: 9023360
  79. Peptidoglycan structure of Salmonella typhimurium growing within cultured mammalian cells.
    Mol Microbiol. 1997 Feb;23(4):693-704 PMID: 9157241
  80. Regulation of lipid A modifications by Salmonella typhimurium virulence genes phoP-phoQ.
    Science. 1997 Apr 11;276(5310):250-3 PMID: 9092473
  81. The spv genes on the Salmonella dublin virulence plasmid are required for severe enteritis and systemic infection in the natural host.
    Infect Immun. 1997 May;65(5):1786-92 PMID: 9125562
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
Published
2001-03-00
Pages
1835-42
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC95077
Subset
IM
Grants
NIAID NIH HHS · R01 AI042236 · United States
NIAID NIH HHS · R56 AI042236 · United States
NIAID NIH HHS · AI42236 · United States
NIGMS NIH HHS · GM54900 · United States
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