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PMID: 11786473 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The developing relationship between receptor-operated and store-operated calcium channels in smooth muscle.

British journal of pharmacology ·Vol. 135 ·No. 1 ·2002-01-00 ·Pages 1-13

McFadzean I, Gibson A

Abstract

Contraction of smooth muscle is initiated, and to a lesser extent maintained, by a rise in the concentration of free calcium in the cell cytoplasm ([Ca(2+)](i)). This activator calcium can originate from two intimately linked sources--the extracellular space and intracellular stores, most notably the sarcoplasmic reticulum. Smooth muscle contraction activated by excitatory neurotransmitters or hormones usually involves a combination of calcium release and calcium entry. The latter occurs through a variety of calcium permeable ion channels in the sarcolemma membrane. The best-characterized calcium entry pathway utilizes voltage-operated calcium channels (VOCCs). However, also present are several types of calcium-permeable channels which are non-voltage-gated, including the so-called receptor-operated calcium channels (ROCCs), activated by agonists acting on a range of G-protein-coupled receptors, and store-operated calcium channels (SOCCs), activated by depletion of the calcium stores within the sarcoplasmic reticulum. In this article we will review the electrophysiological, functional and pharmacological properties of ROCCs and SOCCs in smooth muscle and highlight emerging evidence that suggests that the two channel types may be closely related, being formed from proteins of the Transient Receptor Potential Channel (TRPC) family.

MeSH Terms
Animals Calcium/metabolism Calcium Channels/drug effects,physiology Calcium-Binding Proteins/metabolism Cytoplasm/metabolism Humans Membrane Potentials/drug effects Muscle Contraction/drug effects Muscle, Smooth/physiology Receptors, Cytoplasmic and Nuclear/metabolism Sarcoplasmic Reticulum/metabolism
Chemicals
Calcium Channels Calcium-Binding Proteins Receptors, Cytoplasmic and Nuclear Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
McFadzean Ian
Centre for Cardiovascular Biology & Medicine, School of Biomedical Sciences, King's College London, Hodgkin Building, Guys Campus, London SE1 9RT. [email protected]
Gibson Alan
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1038/sj.bjp.0704468
Email
[email protected]
Published
2002-01-00
Pages
1-13
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1573126
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.bjp.0704468 PMC Full Text View journal details
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