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PMID: 12426142 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Activation of nuclear factor-kappaB and not activator protein-1 in cellular response to nickel compounds.

Environmental health perspectives ·Vol. 110 Suppl 5 ·2002-10-00 ·Pages 835-9

Huang Y, Davidson G, Li J, Yan Y, Chen F, Costa M, Chen LC, Huang C

Abstract

The predominant exposure route for nickel compounds is by inhalation, and several studies have indicated the correlation between nickel exposure and respiratory cancers. The tumor-promoting effects of nickel compounds are thought to be associated with their transactivation of transcription factors. We have investigated the possible activation of activator protein-1 (AP-1) and nuclear factor KB (NF-kappaB) in mouse C141 epidermal cells and fibroblasts 3T3 and B82, and human bronchoepithelial BEAS-2B cells in response to nickel compound exposure. Our results show that NF-kappaB activity is induced by nickel exposure in 3T3 and BEAS-2B cells. Conversely, similar nickel treatment of these cells did not induce AP-1 activity, suggesting that nickel tumorigenesis occurs through NF-kappaB and not AP-1. We also investigated the role of NF-kappaB in the induction of Cap43 by nickel compounds using dominant negative mutant Ikappabeta kinase b-KM BEAS-2B transfectants.

MeSH Terms
Animals Cell Culture Techniques Fibroblasts Humans Inhalation Exposure Lung/cytology Mice NF-kappa B/biosynthesis Nickel/adverse effects Plasmids Skin/cytology Transcription Factor AP-1/biosynthesis Transcription, Genetic/drug effects Transfection
Chemicals
NF-kappa B Transcription Factor AP-1 Nickel
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Huang Yi
Monroe-Woodbury High School, Central Valley, New York, USA.
Davidson Gerard
Li Jingxia
Yan Yan
Chen Fei
Costa Max
Chen Lung Chi
Huang Chuanshu
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Article Info
Journal
Environmental health perspectives
Abbr.
Environ Health Perspect
ISSN
0091-6765
DOI
10.1289/ehp.02110s5835
Published
2002-10-00
Pages
835-9
Language
English
Region
United States
NLM ID
0330411
PMCID
PMC1241256
Subset
IM
Grants
NCI NIH HHS · CA 16087 · United States
NIEHS NIH HHS · ES 00260 · United States
External Links
PubMed source DOI: 10.1289/ehp.02110s5835 PMC Full Text View journal details
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