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PMID: 1316490 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Efficient production of human immunodeficiency virus proteins in transgenic mice.

Journal of virology ·Vol. 66 ·No. 6 ·1992-06-00 ·Pages 3904-8

Jolicoeur P, Laperrière A, Beaulieu N

Abstract

Transgenic mice containing the complete human immunodeficiency virus (HIV) coding sequences fused to the mouse mammary tumor virus long terminal repeat were generated. They were found to produce high levels of authentic gag and env HIV proteins in several tissues known to support mouse mammary tumor virus-driven transcription. HIV proteins were also detected in serum and in body fluids (milk and epididymal secretions) known to be natural sites of retrovirus, and specifically of HIV, production. These results indicate that primary mouse cells from different tissues have the capacity to produce HIV proteins. These mice represent a novel animal model for HIV infection.

MeSH Terms
Animals Gene Products, gag/biosynthesis Genetic Vectors/genetics HIV/genetics Mammary Tumor Virus, Mouse/genetics Mice Mice, Transgenic Tissue Distribution Viral Envelope Proteins/biosynthesis Viral Proteins/biosynthesis
Chemicals
Gene Products, gag Viral Envelope Proteins Viral Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Jolicoeur P
Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Québec, Canada.
Laperrière A
Beaulieu N
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.66.6.3904-3908.1992
Published
1992-06-00
Pages
3904-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC241179
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.66.6.3904-3908.1992 PMC Full Text View journal details
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