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PMID: 14582206 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Inhibition of host protein synthesis and degradation of cellular mRNAs during infection by influenza and herpes simplex virus.

Molecular and cellular biology ·Vol. 2 ·No. 12 ·1982-12-00 ·Pages 1644-8

Inglis SC

Abstract

Cloned DNA copies of two cellular genes were used to monitor, by blot hybridization, the stability of particular cell mRNAs after infection by influenza virus and herpesvirus. The results indicated that the inhibition of host cell protein synthesis that accompanied infection by each virus could be explained by a reduction in the amounts of cellular mRNAs in the cytoplasm, and they suggested that this decrease was due to virus-mediated mRNA degradation.

MeSH Terms
Actins/genetics,metabolism Animals Cells, Cultured Chick Embryo Cricetinae Fibroblasts/cytology,physiology Glyceraldehyde-3-Phosphate Dehydrogenases/genetics,metabolism Orthomyxoviridae/physiology Peptides/genetics,metabolism RNA, Messenger/metabolism Simplexvirus/physiology
Chemicals
Actins Peptides RNA, Messenger Glyceraldehyde-3-Phosphate Dehydrogenases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Inglis S C
Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, England.
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.2.12.1644-1648.1982
Published
1982-12-00
Pages
1644-8
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC369973
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.2.12.1644-1648.1982 PMC Full Text View journal details
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