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PMID: 14681372 Published · ppublish English Journal Article Multicenter Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

UniProt: the Universal Protein knowledgebase.

Nucleic acids research ·Vol. 32 ·No. Database issue ·2004-01-01 ·Pages D115-9

Apweiler R, Bairoch A, Wu CH, Barker WC, Boeckmann B, Ferro S, Gasteiger E, Huang H, Lopez R, Magrane M, Martin MJ, Natale DA, O'Donovan C, Redaschi N, Yeh LS

Abstract

To provide the scientific community with a single, centralized, authoritative resource for protein sequences and functional information, the Swiss-Prot, TrEMBL and PIR protein database activities have united to form the Universal Protein Knowledgebase (UniProt) consortium. Our mission is to provide a comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase, with extensive cross-references and query interfaces. The central database will have two sections, corresponding to the familiar Swiss-Prot (fully manually curated entries) and TrEMBL (enriched with automated classification, annotation and extensive cross-references). For convenient sequence searches, UniProt also provides several non-redundant sequence databases. The UniProt NREF (UniRef) databases provide representative subsets of the knowledgebase suitable for efficient searching. The comprehensive UniProt Archive (UniParc) is updated daily from many public source databases. The UniProt databases can be accessed online (http://www.uniprot.org) or downloaded in several formats (ftp://ftp.uniprot.org/pub). The scientific community is encouraged to submit data for inclusion in UniProt.

MeSH Terms

Animals Computational Biology Databases, Protein Humans Internet Protein Conformation Proteins/chemistry,classification,metabolism Proteome Proteomics Terminology as Topic

Chemicals

Proteins Proteome

Authors & Affiliations

15 authors, click to expand affiliations / ORCID

Apweiler Rolf

The EMBL Outstation--European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. [email protected]

Bairoch Amos

Wu Cathy H

Barker Winona C

Boeckmann Brigitte

Ferro Serenella

Gasteiger Elisabeth

Huang Hongzhan

Lopez Rodrigo

Magrane Michele

Martin Maria J

Natale Darren A

O'Donovan Claire

Redaschi Nicole

Yeh Lai-Su L

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Article Info

Journal

Nucleic acids research

Abbr.

Nucleic Acids Res

ISSN

1362-4962

DOI

10.1093/nar/gkh131

[email protected]

Published

2004-01-01

Pages

D115-9

Language

English

Region

England

NLM ID

0411011

PMCID

PMC308865

Subset

Grants

NHGRI NIH HHS · U01 HG002712 · United States

NHGRI NIH HHS · 1 U01 HG02712-01 · United States

NHGRI NIH HHS · 1R01HGO2273-01 · United States

External Links

PubMed source DOI: 10.1093/nar/gkh131 PMC Full Text View journal details

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