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PMID: 15169849 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing.

The Journal of physiology ·Vol. 558 ·No. Pt 2 ·2004-07-15 ·Pages 659-69

Roza C, Puel JL, Kress M, Baron A, Diochot S, Lazdunski M, Waldmann R

Abstract

Mechanosensitive cation channels are thought to be crucial for different aspects of mechanoperception, such as hearing and touch sensation. In the nematode C. elegans, the degenerins MEC-4 and MEC-10 are involved in mechanosensation and were proposed to form mechanosensitive cation channels. Mammalian degenerin homologues, the H(+)-gated ASIC channels, are expressed in sensory neurones and are therefore interesting candidates for mammalian mechanosensors. We investigated the effect of an ASIC2 gene knockout in mice on hearing and on cutaneous mechanosensation and visceral mechanonociception. However, our data do not support a role of ASIC2 in those facets of mechanoperception.

MeSH Terms
Acid Sensing Ion Channels Animals Auditory Threshold Gene Deletion Hearing/physiology Mechanoreceptors/physiology Membrane Proteins/chemistry,genetics,physiology Mice Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins/chemistry,genetics,physiology Nociceptors/physiology Oocytes/physiology Patch-Clamp Techniques Protein Structure, Tertiary Skin/innervation Sodium Channels/chemistry,genetics,physiology Visceral Afferents/physiology Xenopus laevis
Chemicals
ASIC2 protein, mouse Acid Sensing Ion Channels Membrane Proteins Nerve Tissue Proteins Sodium Channels
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Roza Carolina
Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France.
Puel Jean-Luc
Kress Michaela
Baron Anne
Diochot Sylvie
Lazdunski Michel
Waldmann Rainer
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.2004.066001
Published
2004-07-15
Epub
2004-00-28
Pages
659-69
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1664970
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.2004.066001 PMC Full Text View journal details
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