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PMID: 15491504 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The central role of Fas-ligand cell signaling in inflammatory lung diseases.

Journal of cellular and molecular medicine ·Vol. 8 ·No. 3 ·2004-00-00 ·Pages 285-93

Dosreis GA, Borges VM, Zin WA

Abstract

Following inflammation and injury in the lung, loss of epithelial cell precursors could determine the balance between tissue regeneration and fibrosis. This review discusses evidence that proapoptotic Fas-Fas ligand (FasL) signaling plays a central role in pulmonary inflammation, injury and fibrosis. FasL signaling induces inflammatory apoptosis in epithelial cells and alveolar macrophages, with concomitant IL-1 beta and chemokine release, leading to neutrophil infiltration. FasL signaling plays a critical role in models of acute lung injury, idiopathic pulmonary fibrosis and silicosis; blockade of Fas-FasL interactions either prevents or attenuates pulmonary inflammation and fibrosis. Serologic and immunohistochemical studies in patients support a major pathogenic role of Fas and FasL molecules in inflammatory lung diseases. Identification of the pathogenic role of FasL could facilitate the discovery of more effective treatments for currently untreatable inflammatory lung diseases.

MeSH Terms
Acute Disease Apoptosis Epithelial Cells/metabolism,pathology Fas Ligand Protein Gene Expression Regulation Humans Interleukin-1/metabolism Macrophages, Alveolar/immunology,pathology Membrane Glycoproteins/physiology Neutrophils/immunology Pneumonia/immunology,metabolism Pulmonary Alveoli/immunology,metabolism Pulmonary Fibrosis/immunology,metabolism Signal Transduction Silicosis/immunology fas Receptor/immunology
Chemicals
FASLG protein, human Fas Ligand Protein Interleukin-1 Membrane Glycoproteins fas Receptor
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dosreis G A
Instituto de Biofísica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21949-900, Brazil. [email protected]
Borges Valeria M
Zin W A
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Article Info
Journal
Journal of cellular and molecular medicine
Abbr.
J Cell Mol Med
ISSN
1582-1838
DOI
10.1111/j.1582-4934.2004.tb00318.x
Email
[email protected]
Published
2004-00-00
Pages
285-93
Language
English
Region
England
NLM ID
101083777
PMCID
PMC6740074
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1582-4934.2004.tb00318.x PMC Full Text View journal details
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