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PMID: 16285855 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Concerted and birth-and-death evolution of multigene families.

Annual review of genetics ·Vol. 39 ·2005-00-00 ·Pages 121-52

Nei M, Rooney AP

Abstract

Until around 1990, most multigene families were thought to be subject to concerted evolution, in which all member genes of a family evolve as a unit in concert. However, phylogenetic analysis of MHC and other immune system genes showed a quite different evolutionary pattern, and a new model called birth-and-death evolution was proposed. In this model, new genes are created by gene duplication and some duplicate genes stay in the genome for a long time, whereas others are inactivated or deleted from the genome. Later investigations have shown that most non-rRNA genes including highly conserved histone or ubiquitin genes are subject to this type of evolution. However, the controversy over the two models is still continuing because the distinction between the two models becomes difficult when sequence differences are small. Unlike concerted evolution, the model of birth-and-death evolution can give some insights into the origins of new genetic systems or new phenotypic characters.

MeSH Terms
Animals Evolution, Molecular Humans Multigene Family/genetics Selection, Genetic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Nei Masatoshi
Institute of Molecular Evolutionary Genetics and Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA. [email protected]
Rooney Alejandro P
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Article Info
Journal
Annual review of genetics
Abbr.
Annu Rev Genet
ISSN
0066-4197
DOI
10.1146/annurev.genet.39.073003.112240
Email
[email protected]
Published
2005-00-00
Pages
121-52
Language
English
Region
United States
NLM ID
0117605
PMCID
PMC1464479
Subset
IM
Grants
NIGMS NIH HHS · R01 GM020293 · United States
NIGMS NIH HHS · GM020293-32 · United States
NIGMS NIH HHS · R01 GM020293-33A2 · United States
External Links
PubMed source DOI: 10.1146/annurev.genet.39.073003.112240 PMC Full Text View journal details
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