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PMID: 16936737 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Retinoblastoma family genes.

Oncogene ·Vol. 25 ·No. 38 ·2006-08-28 ·Pages 5190-200

Du W, Pogoriler J

Abstract

The retinoblastoma gene Rb was the first tumor suppressor gene cloned, and it is well known as a negative regulator of the cell cycle through its ability to bind the transcription factor E2F and repress transcription of genes required for S phase. Although over 100 other proteins have been reported to interact with Rb, in most cases these interactions are much less well characterized. Therefore, this review will primarily focus on Rb and E2F interactions. In addition to cell cycle regulation, studies of Rb and E2F proteins in animal models have revealed important roles for these proteins in apoptosis and differentiation. Recent screens of Rb/E2F target genes have identified new targets in all these areas. In addition, the mechanisms determining how different subsets of target genes are regulated under different conditions have only begun to be addressed and offer exciting possibilities for future research.

MeSH Terms
Animals Apoptosis Cell Differentiation Eye Neoplasms/genetics,pathology Gene Expression Regulation, Neoplastic Genes, Retinoblastoma Humans Mammals Multigene Family Retinoblastoma/genetics,pathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Du W
Ben May Institute for Cancer Research and Center for Molecular Oncology, University of Chicago, Chicago, IL 60637, USA. [email protected]
Pogoriler J
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Article Info
Journal
Oncogene
Abbr.
Oncogene
ISSN
0950-9232
DOI
10.1038/sj.onc.1209651
Email
[email protected]
Published
2006-08-28
Pages
5190-200
Language
English
Region
England
NLM ID
8711562
PMCID
PMC1899835
Subset
IM
Grants
NIGMS NIH HHS · R01 GM074197 · United States
External Links
PubMed source DOI: 10.1038/sj.onc.1209651 PMC Full Text View journal details
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