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PMID: 17046688 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1.

Neuron ·Vol. 52 ·No. 2 ·2006-10-19 ·Pages 247-54

Huberman AD, Speer CM, Chapman B

Abstract

The mechanisms that give rise to ocular dominance columns (ODCs) during development are controversial. Early experiments indicated a key role for retinal activity in ODC formation. However, later studies showed that in those early experiments, the retinal activity perturbation was initiated after ODCs had already formed. Moreover, recent studies concluded that early eye removals do not impact ODC segregation. Here we blocked spontaneous retinal activity during the very early stages of ODC development. This permanently disrupted the anatomical organization of ODCs and led to a dramatic increase in receptive field size for binocular cells in primary visual cortex. Our data suggest that early spontaneous retinal activity conveys crucial information about whether thalamocortical axons represent one or the other eye and that this activity mediates binocular competition important for shaping receptive fields in primary visual cortex.

MeSH Terms
Action Potentials/physiology Aging/physiology Animals Animals, Newborn Bridged Bicyclo Compounds, Heterocyclic/pharmacology Cell Communication/physiology Cell Differentiation/physiology Cues Dominance, Ocular/physiology Ferrets Geniculate Bodies/cytology,growth & development Neuronal Plasticity/physiology Nicotinic Agonists/pharmacology Pyridines/pharmacology Retina/cytology,growth & development Synaptic Transmission/physiology Vision, Binocular/physiology Visual Cortex/cytology,growth & development Visual Fields/physiology Visual Pathways/cytology,growth & development
Chemicals
Bridged Bicyclo Compounds, Heterocyclic Nicotinic Agonists Pyridines epibatidine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Huberman Andrew D
Center for Neuroscience, University of California, Davis, Davis, California 95616, USA.
Speer Colenso M
Chapman Barbara
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Article Info
Journal
Neuron
Abbr.
Neuron
ISSN
0896-6273
DOI
10.1016/j.neuron.2006.07.028
Published
2006-10-19
Pages
247-54
Language
English
Region
United States
NLM ID
8809320
PMCID
PMC2647846
Subset
IM
Grants
NEI NIH HHS · R01 EY011369 · United States
NEI NIH HHS · R01 EY011369-11 · United States
Corrections
CommentIn
PMID: 17046683
External Links
PubMed source DOI: 10.1016/j.neuron.2006.07.028 PMC Full Text View journal details
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