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PMID: 17341130 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

A burst-based "Hebbian" learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinement.

PLoS biology ·Vol. 5 ·No. 3 ·2007-03-00 ·Pages e61

Butts DA, Kanold PO, Shatz CJ

Abstract

Patterned spontaneous activity in the developing retina is necessary to drive synaptic refinement in the lateral geniculate nucleus (LGN). Using perforated patch recordings from neurons in LGN slices during the period of eye segregation, we examine how such burst-based activity can instruct this refinement. Retinogeniculate synapses have a novel learning rule that depends on the latencies between pre- and postsynaptic bursts on the order of one second: coincident bursts produce long-lasting synaptic enhancement, whereas non-overlapping bursts produce mild synaptic weakening. It is consistent with "Hebbian" development thought to exist at this synapse, and we demonstrate computationally that such a rule can robustly use retinal waves to drive eye segregation and retinotopic refinement. Thus, by measuring plasticity induced by natural activity patterns, synaptic learning rules can be linked directly to their larger role in instructing the patterning of neural connectivity.

MeSH Terms
Animals Brain/cytology,physiology Learning Neuronal Plasticity Neurons/cytology Synapses/physiology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Butts Daniel A
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, United States of America. [email protected]
Kanold Patrick O
Shatz Carla J
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Article Info
Journal
PLoS biology
Abbr.
PLoS Biol
ISSN
1545-7885
DOI
10.1371/journal.pbio.0050061
Email
[email protected]
Published
2007-03-00
Pages
e61
Language
English
Region
United States
NLM ID
101183755
PMCID
PMC1808114
Subset
IM
Grants
NEI NIH HHS · F32 EY1352 · United States
NEI NIH HHS · F32 EY013526-01 · United States
NEI NIH HHS · R01 EY002858 · United States
NEI NIH HHS · R01 EY02858 · United States
NEI NIH HHS · F32 EY013526 · United States
External Links
PubMed source DOI: 10.1371/journal.pbio.0050061 PMC Full Text View journal details
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