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PMID: 18007680 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Protective immune mechanisms in helminth infection.

Nature reviews. Immunology ·Vol. 7 ·No. 12 ·2007-12-00 ·Pages 975-87

Anthony RM, Rutitzky LI, Urban JF, Stadecker MJ, Gause WC

Abstract

Important insights have recently been gained in our understanding of how host immune responses mediate resistance to parasitic helminths and control associated pathological responses. Although similar cells and cytokines are evoked in response to infection by helminths as diverse as nematodes and schistosomes, the components of the response that mediate protection are dependent on the particular parasite. In this Review, we examine recent findings regarding the mechanisms of protection in helminth infections that have been elucidated in murine models and discuss the implications of these findings in terms of future therapies.

MeSH Terms
Animals Basophils/physiology Cytokines/physiology Eosinophils/physiology Granuloma/immunology Helminthiasis/immunology Humans Immunity, Innate Macrophages/immunology Mast Cells/physiology Neutrophils/immunology T-Lymphocytes, Regulatory/physiology Th2 Cells/immunology
Chemicals
Cytokines
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Anthony Robert M
The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.
Rutitzky Laura I
Urban Joseph F
Stadecker Miguel J
Gause William C
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri2199
Published
2007-12-00
Pages
975-87
Language
English
Region
England
NLM ID
101124169
PMCID
PMC2258092
Subset
IM
Grants
NIAID NIH HHS · AI066188 · United States
NIAID NIH HHS · R01 AI031678-08 · United States
NIAID NIH HHS · R01 AI066188-01A1 · United States
NIAID NIH HHS · R01 AI031678-11 · United States
NIAID NIH HHS · R01 AI031678-13 · United States
NIAID NIH HHS · R01 AI066188-03 · United States
NIAID NIH HHS · AI031678 · United States
NIAID NIH HHS · R01 AI031678 · United States
NIAID NIH HHS · R01 AI031678-06 · United States
NIAID NIH HHS · R01 AI031678-09 · United States
NIAID NIH HHS · R01 AI066188-02 · United States
NIAID NIH HHS · R01 AI031678-12 · United States
NIAID NIH HHS · R01 AI031678-07 · United States
NIAID NIH HHS · R01 AI031678-10 · United States
NIAID NIH HHS · R01 AI031678-14 · United States
NIAID NIH HHS · R01 AI066188 · United States
External Links
PubMed source DOI: 10.1038/nri2199 PMC Full Text View journal details
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