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PMID: 19348869 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Structure and synthesis of polyisoprenoids used in N-glycosylation across the three domains of life.

Biochimica et biophysica acta ·Vol. 1790 ·No. 6 ·2009-06-00 ·Pages 485-94

Jones MB, Rosenberg JN, Betenbaugh MJ, Krag SS

Abstract

N-linked protein glycosylation was originally thought to be specific to eukaryotes, but evidence of this post-translational modification has now been discovered across all domains of life: Eucarya, Bacteria, and Archaea. In all cases, the glycans are first assembled in a step-wise manner on a polyisoprenoid carrier lipid. At some stage of lipid-linked oligosaccharide synthesis, the glycan is flipped across a membrane. Subsequently, the completed glycan is transferred to specific asparagine residues on the protein of interest. Interestingly, though the N-glycosylation pathway seems to be conserved, the biosynthetic pathways of the polyisoprenoid carriers, the specific structures of the carriers, and the glycan residues added to the carriers vary widely. In this review we will elucidate how organisms in each basic domain of life synthesize the polyisoprenoids that they utilize for N-linked glycosylation and briefly discuss the subsequent modifications of the lipid to generate a lipid-linked oligosaccharide.

MeSH Terms
Animals Archaea/chemistry,metabolism Bacteria/chemistry,metabolism Carbohydrate Conformation Carbohydrate Sequence Eukaryotic Cells/chemistry,metabolism Glycosylation Molecular Sequence Data Molecular Structure Polysaccharides/biosynthesis,chemistry Terpenes/chemistry,metabolism
Chemicals
Polysaccharides Terpenes
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Jones Meredith B
Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Rosenberg Julian N
Betenbaugh Michael J
Krag Sharon S
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Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/j.bbagen.2009.03.030
Published
2009-06-00
Epub
2009-00-05
Pages
485-94
Language
English
Region
Netherlands
NLM ID
0217513
PMCID
PMC2755495
Subset
IM
Grants
NIGMS NIH HHS · R01 GM077530 · United States
NIGMS NIH HHS · R01 GM077530-03 · United States
External Links
PubMed source DOI: 10.1016/j.bbagen.2009.03.030 PMC Full Text
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