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PMID: 19394247 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Hsps and aging.

Trends in endocrinology and metabolism: TEM ·Vol. 20 ·No. 5 ·2009-07-00 ·Pages 216-22

Tower J

Abstract

Heat-shock proteins (Hsps) are increasingly being implicated in aging phenotypes and control of life span across species. They are targets of the conserved heat-shock factor and insulin/IGF1-like signaling pathways that affect life span and aging phenotypes. Hsps are expressed in tissue-specific and disease-specific patterns during aging, and their level of expression and induction by stress correlates with and, in some instances, predicts life span. In model organisms, Hsps have been shown to increase life span and ameliorate aging-associated proteotoxicity. Finally, Hsps have emerged as key components in regulating aging-related cellular phenotypes, including cell senescence, apoptosis and cancer. The Hsps, therefore, provide a metric of individual stress and aging and are potential targets for interventions in aging and aging-related diseases.

MeSH Terms
Aging/metabolism,physiology Animals Apoptosis/physiology Cellular Senescence/physiology Heat-Shock Proteins/metabolism,physiology Humans Longevity/physiology Models, Biological
Chemicals
Heat-Shock Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Tower John
Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089-2910, USA. [email protected]
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Article Info
Journal
Trends in endocrinology and metabolism: TEM
Abbr.
Trends Endocrinol Metab
ISSN
1879-3061
DOI
10.1016/j.tem.2008.12.005
Email
[email protected]
Published
2009-07-00
Epub
2009-00-24
Pages
216-22
Language
English
Region
United States
NLM ID
9001516
PMCID
PMC3835556
Subset
IM
Grants
NIEHS NIH HHS · P30 ES007048 · United States
NIA NIH HHS · R01 AG011833 · United States
NIA NIH HHS · AG11833 · United States
NIEHS NIH HHS · 5P30ES007048 · United States
NIA NIH HHS · U19 AG032122 · United States
External Links
PubMed source DOI: 10.1016/j.tem.2008.12.005 PMC Full Text View journal details
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