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PMID: 19580746 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Structural and viscoelastic properties of actin/filamin networks: cross-linked versus bundled networks.

Biophysical journal ·Vol. 97 ·No. 1 ·2009-07-08 ·Pages 83-9

Schmoller KM, Lieleg O, Bausch AR

Abstract

The high diversity of cytoskeletal actin structures is accomplished by myriads of actin binding proteins (ABPs). Depending on its concentration, even a single type of ABP can induce different actin microstructures. Thus, for an overall understanding of the cytoskeleton, a detailed characterization of the cross-linker's effect on structural and mechanical properties of actin networks is required for each ABP. Using confocal microscopy and macrorheology, we investigate both cross-linked and bundled actin/filamin networks and compare their microstructures as well as their viscoelastic properties in the linear and the nonlinear regime.

MeSH Terms
Actins/chemistry Animals Chickens Contractile Proteins/chemistry Cytoskeleton/chemistry Elastic Modulus Elasticity Filamins Microfilament Proteins/chemistry Microscopy, Confocal Probability Protein Structure, Quaternary Rabbits Viscosity
Chemicals
Actins Contractile Proteins Filamins Microfilament Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Schmoller K M
Lehrstuhl für Zellbiophysik E27, Technische Universität München, Garching, Germany.
Lieleg O
Bausch A R
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
1542-0086
DOI
10.1016/j.bpj.2009.04.040
Published
2009-07-08
Pages
83-9
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC2711384
Subset
IM
External Links
PubMed source DOI: 10.1016/j.bpj.2009.04.040 PMC Full Text View journal details
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