Home LiteratureArticle Details
PMID: 19657341 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

RecQ helicases: multifunctional genome caretakers.

Nature reviews. Cancer ·Vol. 9 ·No. 9 ·2009-09-00 ·Pages 644-54

Chu WK, Hickson ID

Abstract

Around 1% of the open reading frames in the human genome encode predicted DNA and RNA helicases. One highly conserved group of DNA helicases is the RecQ family. Genetic defects in three of the five human RecQ helicases, BLM, WRN and RECQ4, give rise to defined syndromes associated with cancer predisposition, some features of premature ageing and chromosomal instability. In recent years, there has been a tremendous advance in our understanding of the cellular functions of individual RecQ helicases. In this Review, we discuss how these proteins might suppress genomic rearrangements, and therefore function as 'caretaker' tumour suppressors.

MeSH Terms
Gene Rearrangement Genes, Tumor Suppressor Genome, Human Humans Neoplasms/enzymology,genetics,prevention & control RecQ Helicases/physiology
Chemicals
RecQ Helicases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chu Wai Kit
Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.
Hickson Ian D
References (132)
132 references, click to expand
  1. Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51.
    J Biol Chem. 2001 Jun 1;276(22):19375-81 PMID: 11278509
  2. Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase.
    Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3174-9 PMID: 11248051
  3. A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.
    Proc Natl Acad Sci U S A. 1974 Nov;71(11):4508-12 PMID: 4140506
  4. Novel pro- and anti-recombination activities of the Bloom's syndrome helicase.
    Genes Dev. 2007 Dec 1;21(23):3085-94 PMID: 18003860
  5. BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity.
    EMBO J. 2005 Apr 6;24(7):1465-76 PMID: 15775963
  6. The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA.
    Nucleic Acids Res. 2005 Jul 15;33(12):3932-41 PMID: 16024743
  7. A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.
    J Biol Chem. 2006 May 19;281(20):13861-4 PMID: 16595695
  8. RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.
    Genes Dev. 2008 Oct 15;22(20):2843-55 PMID: 18923082
  9. Syndrome-causing mutations of the BLM gene in persons in the Bloom's Syndrome Registry.
    Hum Mutat. 2007 Aug;28(8):743-53 PMID: 17407155
  10. Persistence of DNA threads in human anaphase cells suggests late completion of sister chromatid decatenation.
    Chromosoma. 2008 Apr;117(2):123-35 PMID: 17989990
  11. Small ubiquitin-related modifier (SUMO) binding determines substrate recognition and paralog-selective SUMO modification.
    J Biol Chem. 2008 Oct 24;283(43):29405-15 PMID: 18708356
  12. PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint.
    Cell. 2007 Jan 12;128(1):101-14 PMID: 17218258
  13. The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro.
    Biochemistry. 2002 Nov 19;41(46):13483-8 PMID: 12427008
  14. Role of the BLM helicase in replication fork management.
    DNA Repair (Amst). 2007 Jul 1;6(7):936-44 PMID: 17363339
  15. The RecQ helicase-topoisomerase III-Rmi1 complex: a DNA structure-specific 'dissolvasome'?
    Trends Biochem Sci. 2007 Dec;32(12):538-46 PMID: 17980605
  16. S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast.
    Nature. 2002 Feb 7;415(6872):651-5 PMID: 11807498
  17. The Bloom's syndrome helicase unwinds G4 DNA.
    J Biol Chem. 1998 Oct 16;273(42):27587-92 PMID: 9765292
  18. Mus81-Eme1 are essential components of a Holliday junction resolvase.
    Cell. 2001 Nov 16;107(4):537-48 PMID: 11719193
  19. RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.
    Mol Cell. 2008 Aug 8;31(3):324-36 PMID: 18691965
  20. RecQ helicases: guardian angels of the DNA replication fork.
    Chromosoma. 2008 Jun;117(3):219-33 PMID: 18188578
  21. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity.
    Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13097-102 PMID: 9789047
  22. Structure and function of RecQ DNA helicases.
    Crit Rev Biochem Mol Biol. 2004 Mar-Apr;39(2):79-97 PMID: 15217989
  23. Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells.
    Hum Genet. 1996 Jun;97(6):750-4 PMID: 8641691
  24. Analysis of helicase activity and substrate specificity of Drosophila RECQ5.
    Nucleic Acids Res. 2003 Mar 1;31(5):1554-64 PMID: 12595564
  25. Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.
    J Biol Chem. 2000 Aug 4;275(31):23500-8 PMID: 10825162
  26. Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest.
    EMBO Rep. 2000 Jul;1(1):80-4 PMID: 11256630
  27. High-resolution structure of the E.coli RecQ helicase catalytic core.
    EMBO J. 2003 Oct 1;22(19):4910-21 PMID: 14517231
  28. BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges.
    EMBO J. 2007 Jul 25;26(14):3397-409 PMID: 17599064
  29. Domain mapping of Escherichia coli RecQ defines the roles of conserved N- and C-terminal regions in the RecQ family.
    Nucleic Acids Res. 2003 Jun 1;31(11):2778-85 PMID: 12771204
  30. RecQ helicases: caretakers of the genome.
    Nat Rev Cancer. 2003 Mar;3(3):169-78 PMID: 12612652
  31. Molecular genetics of RecQ helicase disorders.
    Cell Mol Life Sci. 2007 Sep;64(17):2306-22 PMID: 17571213
  32. Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1.
    J Biol Chem. 2005 Jul 29;280(30):28072-84 PMID: 15899892
  33. Evidence for chromosome instability in vivo in Bloom syndrome: increased numbers of micronuclei in exfoliated cells.
    Hum Genet. 1985;71(3):187-91 PMID: 4065890
  34. Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide.
    EMBO J. 2004 Jul 21;23(14):2882-91 PMID: 15241474
  35. Carrier frequency of the Bloom syndrome blmAsh mutation in the Ashkenazi Jewish population.
    Mol Genet Metab. 1998 Aug;64(4):286-90 PMID: 9758720
  36. Substrate length requirements for efficient mitotic recombination in Saccharomyces cerevisiae.
    Mol Cell Biol. 1993 Jul;13(7):3937-50 PMID: 8321201
  37. Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I.
    Nature. 1994 Jan 13;367(6459):138-46 PMID: 8114910
  38. The Werner and Bloom syndrome proteins catalyze regression of a model replication fork.
    Biochemistry. 2006 Nov 28;45(47):13939-46 PMID: 17115688
  39. Pathways and functions of the Werner syndrome protein.
    Mech Ageing Dev. 2005 Jan;126(1):79-86 PMID: 15610765
  40. The Bloom's syndrome gene product is homologous to RecQ helicases.
    Cell. 1995 Nov 17;83(4):655-66 PMID: 7585968
  41. Mutations in the WRN gene in mice accelerate mortality in a p53-null background.
    Mol Cell Biol. 2000 May;20(9):3286-91 PMID: 10757812
  42. The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities.
    J Biol Chem. 2008 Jun 27;283(26):17766-76 PMID: 18448429
  43. The Bloom's syndrome helicase can promote the regression of a model replication fork.
    J Biol Chem. 2006 Aug 11;281(32):22839-46 PMID: 16766518
  44. The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase.
    EMBO J. 2001 Feb 15;20(4):905-13 PMID: 11179234
  45. Human premature aging, DNA repair and RecQ helicases.
    Nucleic Acids Res. 2007;35(22):7527-44 PMID: 18006573
  46. Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4.
    EMBO J. 2009 Mar 4;28(5):568-77 PMID: 19177149
  47. Essential role of limiting telomeres in the pathogenesis of Werner syndrome.
    Nat Genet. 2004 Aug;36(8):877-82 PMID: 15235603
  48. Control of cross-over by single-strand DNA resection.
    Trends Genet. 2003 Aug;19(8):428-31 PMID: 12902160
  49. The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.
    Mol Cell. 2004 Jun 18;14(6):763-74 PMID: 15200954
  50. Enhanced tumor formation in mice heterozygous for Blm mutation.
    Science. 2002 Sep 20;297(5589):2051-3 PMID: 12242442
  51. Identification of Holliday junction resolvases from humans and yeast.
    Nature. 2008 Nov 20;456(7220):357-61 PMID: 19020614
  52. Chromosome instability and tumor predisposition inversely correlate with BLM protein levels.
    DNA Repair (Amst). 2003 Dec 9;2(12):1387-404 PMID: 14642567
  53. Functional role of BLAP75 in BLM-topoisomerase IIIalpha-dependent holliday junction processing.
    J Biol Chem. 2008 Jun 6;283(23):15701-8 PMID: 18390547
  54. Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases.
    Hum Mol Genet. 2003 Nov 1;12(21):2837-44 PMID: 12952869
  55. Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome.
    DNA Repair (Amst). 2006 Feb 3;5(2):172-80 PMID: 16214424
  56. Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.
    Nat Cell Biol. 2009 Jun;11(6):753-60 PMID: 19465922
  57. Excess of rare cancers in Werner syndrome (adult progeria).
    Cancer Epidemiol Biomarkers Prev. 1996 Apr;5(4):239-46 PMID: 8722214
  58. Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.
    Science. 2004 Dec 10;306(5703):1951-3 PMID: 15591207
  59. Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta.
    Nucleic Acids Res. 2000 Apr 1;28(7):1647-55 PMID: 10710432
  60. Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.
    Am J Hum Genet. 1997 Feb;60(2):330-41 PMID: 9012406
  61. Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts.
    Hum Genet. 1981;58(3):310-6 PMID: 7327553
  62. Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.
    Genes Dev. 2007 Dec 15;21(24):3331-41 PMID: 18079179
  63. Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.
    Mech Ageing Dev. 2008 Jan-Feb;129(1-2):79-90 PMID: 18054793
  64. Sumoylation of RecQ helicase controls the fate of dysfunctional telomeres.
    Mol Cell. 2009 Mar 13;33(5):559-69 PMID: 19285940
  65. Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae.
    J Biol Chem. 1998 Apr 17;273(16):9644-50 PMID: 9545297
  66. DNA helicases required for homologous recombination and repair of damaged replication forks.
    Annu Rev Genet. 2006;40:279-306 PMID: 16856806
  67. RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange.
    J Biol Chem. 2005 Jun 17;280(24):23397-407 PMID: 15845538
  68. Caretaker tumour suppressor genes that defend genome integrity.
    Trends Mol Med. 2002 Apr;8(4):179-86 PMID: 11927276
  69. Conferring substrate specificity to DNA helicases: role of the RecQ HRDC domain.
    Structure. 2005 Aug;13(8):1173-82 PMID: 16084389
  70. Instability of lymphocyte chromosomes in a girl with Rothmund-Thomson syndrome.
    J Med Genet. 1994 Jul;31(7):570-2 PMID: 7966195
  71. Unwinding the 'Gordian knot' of helicase action.
    Trends Biochem Sci. 2001 Jan;26(1):47-54 PMID: 11165517
  72. Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue.
    Exp Gerontol. 2006 Feb;41(2):157-68 PMID: 16330174
  73. Chromosome fragile sites.
    Annu Rev Genet. 2007;41:169-92 PMID: 17608616
  74. Structural and functional characterizations reveal the importance of a zinc binding domain in Bloom's syndrome helicase.
    Nucleic Acids Res. 2005 Jun 01;33(10):3109-24 PMID: 15930159
  75. Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast.
    Cell. 2003 Nov 14;115(4):401-11 PMID: 14622595
  76. Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase.
    Nucleic Acids Res. 2006 May 02;34(8):2269-79 PMID: 16670433
  77. Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome.
    Hum Mol Genet. 2005 Mar 15;14(6):813-25 PMID: 15703196
  78. The mutation spectrum in RECQL4 diseases.
    Eur J Hum Genet. 2009 Feb;17(2):151-8 PMID: 18716613
  79. A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.
    Mol Cell Biol. 2003 May;23(10):3417-26 PMID: 12724401
  80. Crystal structure of reverse gyrase: insights into the positive supercoiling of DNA.
    EMBO J. 2002 Feb 1;21(3):418-26 PMID: 11823434
  81. Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene.
    Genes Dev. 1998 Nov 1;12(21):3382-93 PMID: 9808625
  82. RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex.
    EMBO J. 2005 Jun 1;24(11):2024-33 PMID: 15889139
  83. The RecQ gene family in plants.
    J Plant Physiol. 2006 Feb;163(3):287-96 PMID: 16371241
  84. Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.
    Am J Hum Genet. 1979 Mar;31(2):125-35 PMID: 36752
  85. Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.
    Hum Mol Genet. 2005 May 15;14(10):1351-65 PMID: 15829507
  86. Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair.
    Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16906-11 PMID: 18971343
  87. Rothmund-Thomson syndrome associated with trisomy 8 mosaicism.
    J Med Genet. 1990 Apr;27(4):258-60 PMID: 2325107
  88. The Bloom's syndrome helicase suppresses crossing over during homologous recombination.
    Nature. 2003 Dec 18;426(6968):870-4 PMID: 14685245
  89. Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis.
    Mol Cell. 2008 Aug 8;31(3):313-23 PMID: 18691964
  90. The Ashkenazic Jewish Bloom syndrome mutation blmAsh is present in non-Jewish Americans of Spanish ancestry.
    Am J Hum Genet. 1998 Dec;63(6):1685-93 PMID: 9837821
  91. The relationship between homology length and crossing over during the repair of a broken chromosome.
    J Biol Chem. 2000 Oct 6;275(40):30833-8 PMID: 10924495
  92. RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli.
    Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3860-5 PMID: 9108069
  93. Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome.
    Am J Med Genet. 2000 Jan 31;90(3):223-8 PMID: 10678659
  94. Alteration of gene conversion tract length and associated crossing over during plasmid gap repair in nuclease-deficient strains of Saccharomyces cerevisiae.
    Nucleic Acids Res. 2000 Dec 1;28(23):4649-56 PMID: 11095674
  95. RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.
    Genes Dev. 2007 Dec 1;21(23):3073-84 PMID: 18003859
  96. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.
    Mol Cell Biol. 1994 Dec;14(12):8391-8 PMID: 7969174
  97. The HRDC domain of BLM is required for the dissolution of double Holliday junctions.
    EMBO J. 2005 Jul 20;24(14):2679-87 PMID: 15990871
  98. The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases.
    Nucleic Acids Res. 2001 Jul 1;29(13):2843-9 PMID: 11433031
  99. BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome.
    Genes Dev. 2008 Oct 15;22(20):2856-68 PMID: 18923083
  100. A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases.
    Trends Biochem Sci. 1997 Nov;22(11):417-8 PMID: 9397680
  101. [Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases].
    Nihon Yakurigaku Zasshi. 2002 Apr;119(4):219-26 PMID: 11979727
  102. Positional cloning of the Werner's syndrome gene.
    Science. 1996 Apr 12;272(5259):258-62 PMID: 8602509
  103. Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest.
    Mol Cell Biol. 2004 Feb;24(3):1279-91 PMID: 14729972
  104. Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends.
    Cell. 2008 Sep 19;134(6):981-94 PMID: 18805091
  105. Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration.
    Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11118-23 PMID: 16849422
  106. Cancer predisposition caused by elevated mitotic recombination in Bloom mice.
    Nat Genet. 2000 Dec;26(4):424-9 PMID: 11101838
  107. Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1.
    J Biol Chem. 2000 Jul 14;275(28):20963-6 PMID: 10806190
  108. RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination.
    Genes Dev. 1998 Apr 15;12(8):1134-44 PMID: 9553043
  109. RecQ helicases: suppressors of tumorigenesis and premature aging.
    Biochem J. 2003 Sep 15;374(Pt 3):577-606 PMID: 12803543
  110. The double-strand-break repair model for recombination.
    Cell. 1983 May;33(1):25-35 PMID: 6380756
  111. BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates.
    Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4068-73 PMID: 16537486
  112. Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome.
    Nat Genet. 1999 May;22(1):82-4 PMID: 10319867
  113. Replisome assembly and the direct restart of stalled replication forks.
    Nat Rev Mol Cell Biol. 2006 Dec;7(12):932-43 PMID: 17139333
  114. Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.
    Cell. 2005 Jun 17;121(6):887-98 PMID: 15960976
  115. Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex.
    Mol Cell Biol. 2005 Jun;25(11):4476-87 PMID: 15899853
  116. BLM ortholog, Sgs1, prevents aberrant crossing-over by suppressing formation of multichromatid joint molecules.
    Cell. 2007 Jul 27;130(2):259-72 PMID: 17662941
  117. CHROMOSOMAL BREAKAGE IN A RARE AND PROBABLY GENETICALLY DETERMINED SYNDROME OF MAN.
    Science. 1965 Apr 23;148(3669):506-7 PMID: 14263770
  118. Hyperinsulinemia and insulin resistance in Wrn null mice fed a diabetogenic diet.
    Mech Ageing Dev. 2008 Apr;129(4):201-6 PMID: 18295300
  119. Resolution of converging replication forks by RecQ and topoisomerase III.
    Mol Cell. 2008 Jun 20;30(6):779-89 PMID: 18570879
  120. Growth retardation and skin abnormalities of the Recql4-deficient mouse.
    Hum Mol Genet. 2003 Sep 15;12(18):2293-9 PMID: 12915449
  121. Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase.
    Cancer Res. 2001 Mar 1;61(5):1816-9 PMID: 11280729
  122. Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing.
    Nature. 2008 Oct 9;455(7214):770-4 PMID: 18806779
  123. SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae.
    Genetics. 1996 Nov;144(3):935-45 PMID: 8913739
  124. Revisiting the craniosynostosis-radial ray hypoplasia association: Baller-Gerold syndrome caused by mutations in the RECQL4 gene.
    J Med Genet. 2006 Feb;43(2):148-52 PMID: 15964893
  125. Werner syndrome protein limits MYC-induced cellular senescence.
    Genes Dev. 2003 Jul 1;17(13):1569-74 PMID: 12842909
  126. SGS1 is required for telomere elongation in the absence of telomerase.
    Curr Biol. 2001 Jan 23;11(2):125-9 PMID: 11231130
  127. Escherichia coli RecQ protein is a DNA helicase.
    Proc Natl Acad Sci U S A. 1990 Jul;87(14):5363-7 PMID: 2164680
  128. Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability.
    Biochem J. 2006 Sep 15;398(3):319-37 PMID: 16925525
  129. The Bloom's syndrome gene product promotes branch migration of holliday junctions.
    Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6504-8 PMID: 10823897
  130. Identification of RecQL1 as a Holliday junction processing enzyme in human cell lines.
    Nucleic Acids Res. 2005 Oct 31;33(19):6251-7 PMID: 16260474
  131. Role for BLM in replication-fork restart and suppression of origin firing after replicative stress.
    Nat Struct Mol Biol. 2007 Jul;14(7):677-9 PMID: 17603497
  132. Clonal lines of aneuploid cells in Rothmund-Thomson syndrome.
    Am J Med Genet. 1990 Nov;37(3):336-9 PMID: 2260560
Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc2682
Published
2009-09-00
Epub
2009-00-06
Pages
644-54
Language
English
Region
England
NLM ID
101124168
Subset
IM
Grants
Cancer Research UK · United Kingdom
External Links
PubMed source DOI: 10.1038/nrc2682 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2