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PMID: 19763153 Published · ppublish English Journal Article Review

Causes and consequences of microRNA dysregulation in cancer.

Nature reviews. Genetics ·Vol. 10 ·No. 10 ·2009-10-00 ·Pages 704-14

Croce CM

Abstract

Over the past several years it has become clear that alterations in the expression of microRNA (miRNA) genes contribute to the pathogenesis of most--if not all--human malignancies. These alterations can be caused by various mechanisms, including deletions, amplifications or mutations involving miRNA loci, epigenetic silencing or the dysregulation of transcription factors that target specific miRNAs. Because malignant cells show dependence on the dysregulated expression of miRNA genes, which in turn control or are controlled by the dysregulation of multiple protein-coding oncogenes or tumour suppressor genes, these small RNAs provide important opportunities for the development of future miRNA-based therapies.

MeSH Terms
Animals Gene Expression Regulation, Neoplastic/physiology Humans MicroRNAs/genetics Neoplasms/genetics
Chemicals
MicroRNAs
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Croce Carlo M
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, 410 West 10th Avenue, Columbus, OH 43210, USA. [email protected]
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2634
Email
[email protected]
Published
2009-10-00
Pages
704-14
Language
English
Region
England
NLM ID
100962779
PMCID
PMC3467096
Subset
IM
Grants
NCI NIH HHS · P01 CA076259 · United States
NCI NIH HHS · P01 CA076259-050001 · United States
NCI NIH HHS · P01 CA129242 · United States
External Links
PubMed source DOI: 10.1038/nrg2634 PMC Full Text View journal details
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