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PMID: 20026558 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Cognition in mouse models of schizophrenia susceptibility genes.

Schizophrenia bulletin ·Vol. 36 ·No. 2 ·2010-03-00 ·Pages 289-300

Arguello PA, Gogos JA

Abstract

Cognitive deficits are core features of psychiatric disorders and contribute substantially to functional outcome. It is still unclear, however, how cognitive deficits are related to underlying genetic liability and overt clinical symptoms. Fortunately, animal models of susceptibility genes can illuminate how the products of disease-associated genetic variants affect brain function and ultimately alter behavior. Using as a reference findings from the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia program and the SchizophreniaGene database, we review cognitive data from mutant models of rare and common genetic variants associated with schizophrenia.

MeSH Terms
Alleles Animals Brain/physiopathology Cognition Disorders/genetics,physiopathology,psychology Disease Models, Animal Executive Function/physiology Genetic Association Studies Genetic Markers/genetics Genetic Predisposition to Disease/genetics,psychology Humans Memory, Short-Term/physiology Mice Mice, Transgenic Nerve Tissue Proteins/genetics Schizophrenia/genetics,physiopathology Schizophrenic Psychology
Chemicals
DISC1 protein, human Disc1 protein, mouse Genetic Markers Nerve Tissue Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Arguello P Alexander
Department of Neuroscience, Columbia University Medical Center, New York, NY 10032, USA. [email protected]
Gogos Joseph A
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Article Info
Journal
Schizophrenia bulletin
Abbr.
Schizophr Bull
ISSN
1745-1701
DOI
10.1093/schbul/sbp153
Email
[email protected]
Published
2010-03-00
Epub
2009-00-21
Pages
289-300
Language
English
Region
United States
NLM ID
0236760
PMCID
PMC2833129
Subset
IM
Grants
NIMH NIH HHS · MH080234-01A1 · United States
NIMH NIH HHS · R01 MH077235 · United States
External Links
PubMed source DOI: 10.1093/schbul/sbp153 PMC Full Text View journal details
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