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PMID: 20094054 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Understanding cytokinesis: lessons from fission yeast.

Nature reviews. Molecular cell biology ·Vol. 11 ·No. 2 ·2010-00-00 ·Pages 149-55

Pollard TD, Wu JQ

Abstract

For decades after the discovery that a contractile ring made of actin filaments and myosin II produces the force to constrict the cleavage furrow of animal cells, the complexity of cytokinesis has slowed progress in understanding the mechanism. Mechanistic insights, however, have been obtained by genetic, biochemical, microscopic and mathematical modelling approaches in the fission yeast Schizosaccharomyces pombe. Many features that have been identified in fission yeast are probably shared with animal cells, as both inherited many cytokinesis genes from their common ancestor about one billion years ago.

MeSH Terms
Animals Cell Cycle Proteins/genetics,metabolism Cytokinesis Evolution, Molecular Schizosaccharomyces/cytology,genetics,metabolism Schizosaccharomyces pombe Proteins/genetics,metabolism
Chemicals
Cell Cycle Proteins Schizosaccharomyces pombe Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pollard Thomas D
Thomas D. Pollard is at the Department of Molecular Cellular and Developmental Biology, and the Departments of Molecular Biophysics and Biochemistry and of Cell Biology, Yale University, PO BOX 208103, New Haven, Connecticut 06520-8103, USA.
Wu Jian-Qiu
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm2834
Published
2010-00-00
Pages
149-55
Language
English
Region
England
NLM ID
100962782
PMCID
PMC2819279
Subset
IM
Grants
NIGMS NIH HHS · R01 GM086546 · United States
NIGMS NIH HHS · GM-026338 · United States
NIGMS NIH HHS · GM-086546 · United States
NIGMS NIH HHS · R01 GM086546-01 · United States
NIGMS NIH HHS · R01 GM026338 · United States
NIGMS NIH HHS · R01 GM026132 · United States
External Links
PubMed source DOI: 10.1038/nrm2834 PMC Full Text View journal details
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