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PMID: 20159345 Published · ppublish English Journal Article Review

Molecular genetics of attention deficit hyperactivity disorder.

The Psychiatric clinics of North America ·Vol. 33 ·No. 1 ·2010-03-00 ·Pages 159-80

Faraone SV, Mick E

Abstract

Although twin studies demonstrate that ADHD is a highly heritable condition, molecular genetic studies suggest that the genetic architecture of ADHD is complex. The handful of genome-wide linkage and association scans that have been conducted thus far show divergent findings and are, therefore, not conclusive. Similarly, many of the candidate genes reviewed here (ie, DBH, MAOA, SLC6A2, TPH-2, SLC6A4, CHRNA4, GRIN2A) are theoretically compelling from neurobiological systems perspective but available data are sparse and inconsistent. However, candidate gene studies of ADHD have produced substantial evidence implicating several genes in the etiology of the disorder, with meta-analyses supportive of a role of the genes coding for DRD4, DRD5, SLC6A3, SNAP-25, and HTR1B in the etiology of ADHD.

MeSH Terms
Attention Deficit Disorder with Hyperactivity/diagnosis,epidemiology,genetics Gene Expression/genetics Genome-Wide Association Study Humans Molecular Biology/methods Prevalence Twins/genetics
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Faraone Stephen V
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210-2375, USA. [email protected]
Mick Eric
References (163)
163 references, click to expand
  1. Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: the additive and subtractive effect of the three dopaminergic genes--DRD2, D beta H, and DAT1.
    Am J Med Genet. 1996 May 31;67(3):264-88 PMID: 8725745
  2. Association analysis of the monoamine oxidase A and B genes with attention deficit hyperactivity disorder (ADHD) in an Irish sample: preferential transmission of the MAO-A 941G allele to affected children.
    Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):110-4 PMID: 15717295
  3. Lack of association between the tryptophan hydroxylase gene A218C polymorphism and attention-deficit hyperactivity disorder in Chinese Han population.
    Am J Med Genet. 2001 Aug 8;105(6):485-8 PMID: 11496362
  4. Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder.
    Am J Med Genet. 2002 Apr 8;114(3):269-71 PMID: 11920846
  5. The DRD2 TaqI polymorphism and symptoms of attention deficit hyperactivity disorder.
    Mol Psychiatry. 1999 Nov;4(6):580-6 PMID: 10578241
  6. Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD.
    Biol Psychiatry. 2006 Mar 1;59(5):460-7 PMID: 16197923
  7. Molecular genetics of attention-deficit/hyperactivity disorder.
    Biol Psychiatry. 2005 Jun 1;57(11):1313-23 PMID: 15950004
  8. Family-based association study of DAT1 and DRD4 polymorphism in Korean children with ADHD.
    Neurosci Lett. 2005 Dec 30;390(3):176-81 PMID: 16165273
  9. Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention.
    Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4754-9 PMID: 10781080
  10. Sequence variants of the DRD4 gene in autism: further evidence that rare DRD4 7R haplotypes are ADHD specific.
    Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136B(1):33-5 PMID: 15892149
  11. Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD.
    Mol Psychiatry. 2004 Feb;9(2):169-73 PMID: 14966475
  12. Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.
    Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1355-8 PMID: 18937294
  13. Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs.
    J Neurosci. 1998 Sep 1;18(17):6914-27 PMID: 9712661
  14. A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study.
    Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1554-63 PMID: 18937310
  15. A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs.
    Mol Psychiatry. 2006 Feb;11(2):196-205 PMID: 16222334
  16. Lack of significant association between -1021C-->T polymorphism in the dopamine beta hydroxylase gene and attention deficit hyperactivity disorder.
    Neurosci Lett. 2006 Jul 10;402(1-2):12-6 PMID: 16616989
  17. Association of dopamine D4 receptor (DRD4) gene with attention-deficit/hyperactivity disorder (ADHD) in a high-risk community sample: a longitudinal study from birth to 11 years of age.
    J Neural Transm (Vienna). 2004 Jul;111(7):883-9 PMID: 15206004
  18. Dopaminergic system genes in ADHD: toward a biological hypothesis.
    Neuropsychopharmacology. 2002 Oct;27(4):607-19 PMID: 12377397
  19. Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD.
    Mol Psychiatry. 2005 Oct;10(10):944-9 PMID: 15940290
  20. Linkage studies between attention-deficit hyperactivity disorder and the monoamine oxidase genes.
    Am J Med Genet. 2001 Dec 8;105(8):783-8 PMID: 11803531
  21. Family-based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: no evidence for association in UK and Taiwanese samples.
    Am J Med Genet B Neuropsychiatr Genet. 2005 Nov 5;139B(1):11-3 PMID: 16082690
  22. Additive effect of three noradrenergic genes (ADRA2a, ADRA2C, DBH) on attention-deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects.
    Clin Genet. 1999 Mar;55(3):160-72 PMID: 10334470
  23. Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study.
    Am J Med Genet. 2001 Jul 8;105(5):464-70 PMID: 11449400
  24. The psychiatric status of the legal families of adopted hyperactive children.
    Arch Gen Psychiatry. 1973 Jun;28(6):888-91 PMID: 4707995
  25. Attention deficit hyperactivity disorder and the gene for dopamine Beta-hydroxylase.
    Am J Psychiatry. 2002 Jun;159(6):1046-8 PMID: 12042196
  26. Association of attention-deficit disorder and the dopamine transporter gene.
    Am J Hum Genet. 1995 Apr;56(4):993-8 PMID: 7717410
  27. Multiple dopamine D4 receptor variants in the human population.
    Nature. 1992 Jul 9;358(6382):149-52 PMID: 1319557
  28. Genetic polymorphism of catechol-O-methyltransferase (COMT): correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and parkinsonian patients in Finland.
    Pharmacogenetics. 1997 Feb;7(1):65-71 PMID: 9110364
  29. A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder.
    Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19164-9 PMID: 17146058
  30. Association of the low-activity COMT 158Met allele with ADHD and OCD in subjects with velocardiofacial syndrome.
    Int J Neuropsychopharmacol. 2007 Jun;10(3):301-8 PMID: 16734939
  31. The norepinephrine transporter gene and attention-deficit hyperactivity disorder.
    Am J Med Genet. 2002 Apr 8;114(3):255-9 PMID: 11920844
  32. Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.
    Science. 1999 Jan 15;283(5400):397-401 PMID: 9888856
  33. The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.
    Mol Psychiatry. 2006 Oct;11(10):934-53 PMID: 16894395
  34. Polymorphism of DRD2 gene and ADHD.
    Neuro Endocrinol Lett. 2006 Feb-Apr;27(1-2):236-40 PMID: 16648784
  35. Identification of DNA variants in the SNAP-25 gene and linkage study of these polymorphisms and attention-deficit hyperactivity disorder.
    Mol Psychiatry. 2000 Jul;5(4):405-9 PMID: 10889551
  36. DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters.
    Am J Med Genet B Neuropsychiatr Genet. 2005 Nov 5;139B(1):33-7 PMID: 16082702
  37. Association of dopamine D4 receptor (DRD4) polymorphisms with attention deficit hyperactivity disorder in Indian population.
    Am J Med Genet B Neuropsychiatr Genet. 2006 Jan 5;141B(1):61-6 PMID: 16331654
  38. Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorder.
    Clin Genet. 2000 Jul;58(1):31-40 PMID: 10945659
  39. Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci.
    Mol Psychiatry. 2003 Mar;8(3):299-308 PMID: 12660802
  40. No evidence of linkage or association between the norepinephrine transporter (NET) gene polymorphisms and ADHD in the Irish population.
    Am J Med Genet. 2002 Aug 8;114(6):665-6 PMID: 12210284
  41. A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention deficit hyperactivity disorder.
    Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):541-50 PMID: 17440978
  42. The worldwide prevalence of ADHD: is it an American condition?
    World Psychiatry. 2003 Jun;2(2):104-13 PMID: 16946911
  43. Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD.
    Mol Psychiatry. 2004 Aug;9(8):801-10 PMID: 15007392
  44. Polymorphism of the serotonin-2A receptor gene (HTR2A) associated with childhood attention deficit hyperactivity disorder (ADHD) in adult women with seasonal affective disorder.
    J Affect Disord. 2002 Sep;71(1-3):229-33 PMID: 12167522
  45. A transmission disequilibrium test of the Ser9/Gly dopamine D3 receptor gene polymorphism in adult attention-deficit hyperactivity disorder.
    Behav Brain Res. 2002 Mar 10;130(1-2):91-5 PMID: 11864723
  46. A "line item" approach to the identification of genes involved in polygenic behavioral disorders: the adrenergic alpha2A (ADRA2A) gene.
    Am J Med Genet B Neuropsychiatr Genet. 2003 Apr 1;118B(1):110-4 PMID: 12627476
  47. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
    Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1345-54 PMID: 18821565
  48. Collaborative analysis of DRD4 and DAT genotypes in population-defined ADHD subtypes.
    J Child Psychol Psychiatry. 2005 Oct;46(10):1067-73 PMID: 16178930
  49. Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes.
    Am J Hum Genet. 2004 Feb;74(2):348-56 PMID: 14732906
  50. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants.
    J Neurochem. 1995 Sep;65(3):1157-65 PMID: 7643093
  51. Interacting effects of the dopamine transporter gene and psychosocial adversity on attention-deficit/hyperactivity disorder symptoms among 15-year-olds from a high-risk community sample.
    Arch Gen Psychiatry. 2007 May;64(5):585-90 PMID: 17485610
  52. A family-based association study of attention-deficit hyperactivity disorder and dopamine D2 receptor TaqI A alleles.
    Chang Gung Med J. 2003 Dec;26(12):897-903 PMID: 15008324
  53. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD.
    Am J Psychiatry. 2004 Jan;161(1):133-8 PMID: 14702261
  54. Adoptive and biological families of children and adolescents with ADHD.
    J Am Acad Child Adolesc Psychiatry. 2000 Nov;39(11):1432-7 PMID: 11068899
  55. Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C.
    Mol Psychiatry. 2001 May;6(3):334-7 PMID: 11326305
  56. Inferring candidate genes for attention deficit hyperactivity disorder (ADHD) assessed by the World Health Organization Adult ADHD Self-Report Scale (ASRS).
    J Neural Transm (Vienna). 2006 Jul;113(7):929-38 PMID: 16362639
  57. Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene.
    Biol Psychiatry. 1999 Mar 1;45(5):603-14 PMID: 10088047
  58. No evidence for the association of DRD4 with ADHD in a Taiwanese population within-family study.
    BMC Med Genet. 2005 Sep 05;6:31 PMID: 16143039
  59. Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample.
    Mol Psychiatry. 2002;7(7):718-25 PMID: 12192616
  60. Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD.
    Am J Psychiatry. 2007 Apr;164(4):674-7 PMID: 17403983
  61. DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association.
    Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):115-8 PMID: 15719398
  62. Linkage disequilibrium analysis of the dopamine beta-hydroxylase gene in persistent attention deficit hyperactivity disorder.
    Psychiatr Genet. 2004 Jun;14(2):117-20 PMID: 15167700
  63. Association between alpha-2a-adrenergic receptor gene and ADHD inattentive type.
    Biol Psychiatry. 2006 Nov 15;60(10):1028-33 PMID: 16806103
  64. Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B.
    Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5;133B(1):68-73 PMID: 15578613
  65. Attention-deficit/hyperactivity disorder endophenotypes.
    Biol Psychiatry. 2005 Jun 1;57(11):1324-35 PMID: 15950005
  66. Serotonin genes and attention deficit/hyperactivity disorder in a Brazilian sample: preferential transmission of the HTR2A 452His allele to affected boys.
    Am J Med Genet B Neuropsychiatr Genet. 2007 Jan 5;144B(1):69-73 PMID: 16958038
  67. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior.
    Mol Psychiatry. 2003 Jul;8(7):646-53 PMID: 12874600
  68. Neuropsychological endophenotype approach to genome-wide linkage analysis identifies susceptibility loci for ADHD on 2q21.1 and 13q12.11.
    Am J Hum Genet. 2008 Jul;83(1):99-105 PMID: 18599010
  69. Genotypic interaction between DRD4 and DAT1 loci is a high risk factor for attention-deficit/hyperactivity disorder in Chilean families.
    Am J Med Genet B Neuropsychiatr Genet. 2006 Jan 5;141B(1):51-4 PMID: 16342279
  70. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter.
    Nature. 1996 Feb 15;379(6566):606-12 PMID: 8628395
  71. Evidence for the serotonin HTR2A receptor gene as a susceptibility factor in attention deficit hyperactivity disorder (ADHD).
    Mol Psychiatry. 2000 Sep;5(5):537-41 PMID: 11032388
  72. DRD4 gene variants and sustained attention in attention deficit hyperactivity disorder (ADHD): effects of associated alleles at the VNTR and -521 SNP.
    Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136B(1):81-6 PMID: 15909295
  73. A family-based study of Indian subjects from Kolkata reveals allelic association of the serotonin transporter intron-2 (STin2) polymorphism and attention-deficit-hyperactivity disorder (ADHD).
    Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5;141B(4):361-6 PMID: 16583436
  74. Family-based association study of the serotonin transporter gene polymorphisms in Korean ADHD trios.
    Am J Med Genet B Neuropsychiatr Genet. 2005 Nov 5;139B(1):14-8 PMID: 16082698
  75. No association between TPH2 gene polymorphisms and ADHD in a UK sample.
    Neurosci Lett. 2007 Jan 29;412(2):105-7 PMID: 17123708
  76. A genomewide scan for loci involved in attention-deficit/hyperactivity disorder.
    Am J Hum Genet. 2002 May;70(5):1183-96 PMID: 11923911
  77. Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder.
    Genes Brain Behav. 2008 Feb;7(1):53-60 PMID: 17504247
  78. Evidence for linkage of a tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4) with attention deficit hyperactivity disorder (ADHD).
    Mol Psychiatry. 2000 Sep;5(5):531-6 PMID: 11032387
  79. The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects.
    Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):874-6 PMID: 17099886
  80. Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder.
    Am J Psychiatry. 2001 Jul;158(7):1052-7 PMID: 11431226
  81. Is the alpha-2A adrenergic receptor gene (ADRA2A) associated with attention-deficit/hyperactivity disorder?
    Am J Med Genet B Neuropsychiatr Genet. 2003 Jul 1;120B(1):116-20 PMID: 12815749
  82. DAT1, DRD4, and DRD5 polymorphisms are not associated with ADHD in Dutch families.
    Am J Med Genet B Neuropsychiatr Genet. 2005 Jan 5;132B(1):50-2 PMID: 15389755
  83. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.
    Mol Psychiatry. 2005 Dec;10(12):1126-32 PMID: 16116490
  84. Genetics of hyperactivity.
    J Child Psychol Psychiatry. 1975 Jul;16(3):261-4 PMID: 1171894
  85. Pooled genome-wide linkage data on 424 ADHD ASPs suggests genetic heterogeneity and a common risk locus at 5p13.
    Mol Psychiatry. 2006 Jan;11(1):5-8 PMID: 16205734
  86. Gene for the serotonin transporter and ADHD: no association with two functional polymorphisms.
    Am J Med Genet B Neuropsychiatr Genet. 2006 Sep 5;141B(6):566-70 PMID: 16856124
  87. Neural development is regulated by classical neurotransmitters: dopamine D2 receptor stimulation enhances neurite outgrowth.
    Biol Psychiatry. 1992 Apr 15;31(8):794-807 PMID: 1643194
  88. Possible involvement of alpha-2A adrenergic receptors in attention deficit hyperactivity disorder: radioligand binding and polymorphism studies.
    Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):877-84 PMID: 16917924
  89. Diagnosing adult attention deficit hyperactivity disorder: are late onset and subthreshold diagnoses valid?
    Am J Psychiatry. 2006 Oct;163(10):1720-9; quiz 1859 PMID: 17012682
  90. Meta-analysis of family-based association studies between the dopamine transporter gene and attention deficit hyperactivity disorder.
    Psychiatr Genet. 2005 Mar;15(1):53-9 PMID: 15722958
  91. Neurobiology of attention-deficit hyperactivity disorder.
    Biol Psychiatry. 1998 Nov 15;44(10):951-8 PMID: 9821559
  92. Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice.
    Cell. 1994 Dec 16;79(6):945-55 PMID: 8001143
  93. Pharmacotherapy of attention deficit hyperactivity disorder.
    Child Adolesc Psychiatr Clin N Am. 2000 Jan;9(1):77-97 PMID: 10674191
  94. [Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder with or without learning disorder].
    Zhonghua Yi Xue Za Zhi. 2003 Dec 25;83(24):2114-8 PMID: 14720417
  95. Nicotinic acetylcholine receptor alpha4 subunit gene polymorphism and attention deficit hyperactivity disorder.
    Psychiatr Genet. 2001 Mar;11(1):37-40 PMID: 11409698
  96. Linkage study of two polymorphisms at the dopamine D3 receptor gene and attention-deficit hyperactivity disorder.
    Am J Med Genet. 2000 Feb 7;96(1):114-7 PMID: 10686563
  97. A longitudinal look at parent-child diagnostic agreement in youth treated for anxiety disorders.
    J Clin Child Adolesc Psychol. 2005 Dec;34(4):747-57 PMID: 16232071
  98. The adrenergic receptor alpha-2A gene (ADRA2A) and neuropsychological executive functions as putative endophenotypes for childhood ADHD.
    Cogn Affect Behav Neurosci. 2006 Mar;6(1):18-30 PMID: 16869226
  99. Linkage study of the alpha2A adrenergic receptor in attention-deficit hyperactivity disorder families.
    Am J Med Genet. 2001 Mar 8;105(2):159-62 PMID: 11304829
  100. Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD).
    Hum Mol Genet. 2006 Jul 15;15(14):2276-84 PMID: 16774975
  101. Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples.
    Am J Med Genet B Neuropsychiatr Genet. 2007 Jan 5;144B(1):83-6 PMID: 17044097
  102. Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD.
    Mol Psychiatry. 2005 Oct;10(10):939-43 PMID: 15940292
  103. Mutational analysis of the nicotinic acetylcholine receptor alpha 4 subunit gene in attention deficit/hyperactivity disorder: evidence for association of an intronic polymorphism with attention problems.
    Mol Psychiatry. 2003 Jan;8(1):103-8 PMID: 12556914
  104. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.
    Nat Genet. 1995 Nov;11(3):241-7 PMID: 7581446
  105. Comparison of the role of dopamine, serotonin, and noradrenaline genes in ADHD, ODD and conduct disorder: multivariate regression analysis of 20 genes.
    Clin Genet. 2000 Mar;57(3):178-96 PMID: 10782925
  106. The short DRD4 repeats confer risk to attention deficit hyperactivity disorder in a family-based design and impair performance on a continuous performance test (TOVA).
    Mol Psychiatry. 2002;7(7):790-4 PMID: 12192625
  107. Dopa decarboxylase gene polymorphisms and attention deficit hyperactivity disorder (ADHD): no evidence for association in the Irish population.
    Mol Psychiatry. 2001 Jul;6(4):420-4 PMID: 11443526
  108. Association of the dopamine beta hydroxylase gene with attention deficit hyperactivity disorder: genetic analysis of the Milwaukee longitudinal study.
    Am J Med Genet B Neuropsychiatr Genet. 2003 May 15;119B(1):77-85 PMID: 12707943
  109. Dopamine D3 receptor gene polymorphism and violent behavior: relation to impulsiveness and ADHD-related psychopathology.
    J Neural Transm (Vienna). 2003 May;110(5):561-72 PMID: 12721816
  110. Coloboma mouse mutant as an animal model of hyperkinesis and attention deficit hyperactivity disorder.
    Neurosci Biobehav Rev. 2000 Jan;24(1):51-7 PMID: 10654661
  111. Lack of association of dopamine D4 receptor gene polymorphisms with ADHD subtypes in a population sample of twins.
    Am J Med Genet. 2001 Jul 8;105(5):432-8 PMID: 11449395
  112. A whole-genome scan in 164 Dutch sib pairs with attention-deficit/hyperactivity disorder: suggestive evidence for linkage on chromosomes 7p and 15q.
    Am J Hum Genet. 2003 May;72(5):1251-60 PMID: 12679898
  113. Significance of serotonin transporter gene 5-HTTLPR and variable number of tandem repeat polymorphism in attention deficit hyperactivity disorder.
    Neuropsychobiology. 2002;45(4):176-81 PMID: 12097805
  114. Contribution of 5-HT2A receptor gene -1438A>G polymorphism to outcome of attention-deficit/hyperactivity disorder in adolescents.
    Am J Med Genet B Neuropsychiatr Genet. 2006 Jul 5;141B(5):473-6 PMID: 16741915
  115. [Association between dopamine beta hydroxylase gene and attention deficit hyperactivity disorder complicated with disruptive behavior disorder].
    Zhonghua Er Ke Za Zhi. 2005 Jan;43(1):26-30 PMID: 15796803
  116. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
    J Neural Transm (Vienna). 2008 Nov;115(11):1573-85 PMID: 18839057
  117. Non-stimulant treatments for ADHD.
    Eur Child Adolesc Psychiatry. 2000;9 Suppl 1:I51-9 PMID: 11140780
  118. Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism.
    Am J Hum Genet. 2002 Oct;71(4):959-63 PMID: 12187510
  119. 5'-untranslated region of the dopamine D4 receptor gene and attention-deficit hyperactivity disorder.
    Am J Med Genet. 2001 Jan 8;105(1):84-90 PMID: 11425008
  120. Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype.
    Biol Psychiatry. 2007 Jun 15;61(12):1320-8 PMID: 17157268
  121. Clinical and genetic characteristics of Korean male alcoholics with and without attention deficit hyperactivity disorder.
    Alcohol Alcohol. 2006 Jul-Aug;41(4):407-11 PMID: 16679343
  122. Support for association between ADHD and two candidate genes: NET1 and DRD1.
    Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):67-72 PMID: 15717291
  123. The serotonin transporter gene as a QTL for ADHD.
    Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):42-7 PMID: 15719397
  124. Meta-analysis of association between a catechol-O-methyltransferase gene polymorphism and attention deficit hyperactivity disorder.
    Behav Genet. 2006 Sep;36(5):651-9 PMID: 16676224
  125. Association between polymorphisms in serotonin 2C receptor gene and attention-deficit/hyperactivity disorder in Han Chinese subjects.
    Neurosci Lett. 2006 Oct 23;407(2):107-11 PMID: 16959425
  126. Neuropsychological functioning in youth with bipolar disorder.
    Biol Psychiatry. 2005 Oct 1;58(7):540-8 PMID: 16199011
  127. Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sample.
    J Neural Transm (Vienna). 2007;114(4):513-21 PMID: 17093889
  128. Family-based and association studies of monoamine oxidase A and attention deficit hyperactivity disorder (ADHD): preferential transmission of the long promoter-region repeat and its association with impaired performance on a continuous performance test (TOVA).
    Mol Psychiatry. 2002;7(6):626-32 PMID: 12140786
  129. Association and linkage of alpha-2A adrenergic receptor gene polymorphisms with childhood ADHD.
    Mol Psychiatry. 2005 Jun;10(6):572-80 PMID: 15520832
  130. Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children.
    Mol Psychiatry. 1999 Mar;4(2):192-6 PMID: 10208453
  131. Analysis of polymorphisms in the dopamine beta hydroxylase gene: association with attention deficit hyperactivity disorder in Indian children.
    Indian Pediatr. 2005 Feb;42(2):123-9 PMID: 15767706
  132. Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: a study and replication.
    Biol Psychiatry. 1996 Sep 1;40(5):368-72 PMID: 8874837
  133. Association study between the monoamine oxidase A gene and attention deficit hyperactivity disorder in Taiwanese samples.
    BMC Psychiatry. 2007 Feb 28;7:10 PMID: 17328795
  134. The SNAP25 gene as a susceptibility gene contributing to attention-deficit hyperactivity disorder.
    Mol Psychiatry. 2005 Nov;10(11):998-1005, 973 PMID: 16088329
  135. Characterizing the ADHD phenotype for genetic studies.
    Dev Sci. 2005 Mar;8(2):115-21 PMID: 15720369
  136. Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder.
    Am J Med Genet B Neuropsychiatr Genet. 2003 Jan 1;116B(1):84-9 PMID: 12497620
  137. Possible association of the alpha-2A adrenergic receptor gene (ADRA2A) with symptoms of attention-deficit/hyperactivity disorder.
    Am J Med Genet B Neuropsychiatr Genet. 2006 Mar 5;141B(2):130-4 PMID: 16389583
  138. Multiple marker analysis at the promoter region of the DRD4 gene and ADHD: evidence of linkage and association with the SNP -616.
    Am J Med Genet B Neuropsychiatr Genet. 2004 Nov 15;131B(1):33-7 PMID: 15389764
  139. A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy.
    Arch Gen Psychiatry. 2006 Jan;63(1):74-81 PMID: 16389200
  140. Biased paternal transmission of SNAP-25 risk alleles in attention-deficit hyperactivity disorder.
    Mol Psychiatry. 2003 Mar;8(3):309-15 PMID: 12660803
  141. Glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A) gene as a positional candidate for attention-deficit/hyperactivity disorder in the 16p13 region.
    Mol Psychiatry. 2004 May;9(5):494-9 PMID: 14699423
  142. Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder.
    Neuropsychopharmacology. 2004 Jan;29(1):179-86 PMID: 14560322
  143. Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor.
    J Neurochem. 1997 Feb;68(2):804-12 PMID: 9003072
  144. Further evidence for the association between attention-deficit/hyperactivity disorder and the dopamine-beta-hydroxylase gene.
    Am J Med Genet. 2002 Mar 8;114(2):154-8 PMID: 11857576
  145. Pedigree disequilibrium test (PDT) replicates association and linkage between DRD4 and ADHD in multigenerational and extended pedigrees from a genetic isolate.
    Mol Psychiatry. 2004 Mar;9(3):252-9 PMID: 15094785
  146. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.
    Cell. 2003 Jan 24;112(2):257-69 PMID: 12553913
  147. Adrenergic alpha 2C receptor genomic organization: association study in adult ADHD.
    Am J Med Genet B Neuropsychiatr Genet. 2004 May 15;127B(1):65-7 PMID: 15108182
  148. Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5.
    Mol Psychiatry. 2004 Jul;9(7):711-7 PMID: 14699430
  149. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders.
    Mol Psychiatry. 2003 Jun;8(6):574-91 PMID: 12851635
  150. Association of attention-deficit/hyperactivity disorder with serotonin 4 receptor gene polymorphisms in Han Chinese subjects.
    Neurosci Lett. 2006 Jun 19;401(1-2):6-9 PMID: 16563621
  151. No association of attention-deficit/hyperactivity disorder with genes of the serotonergic pathway in Han Chinese subjects.
    Neurosci Lett. 2006 Jul 31;403(1-2):172-5 PMID: 16701945
  152. Temperament and character profiles and the dopamine D4 receptor gene in ADHD.
    Am J Psychiatry. 2005 May;162(5):906-13 PMID: 15863792
  153. Association between polymorphisms in serotonin transporter gene and attention deficit hyperactivity disorder in Chinese Han subjects.
    Am J Med Genet B Neuropsychiatr Genet. 2007 Jan 5;144B(1):14-9 PMID: 16941663
  154. Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder.
    Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1392-8 PMID: 18988193
  155. Two dopamine genes related to reports of childhood retrospective inattention and conduct disorder symptoms.
    Mol Psychiatry. 2001 Jul;6(4):429-33 PMID: 11443528
  156. The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication.
    Am J Psychiatry. 2006 Apr;163(4):716-23 PMID: 16585449
  157. The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder.
    Mol Psychiatry. 2003 Jan;8(1):98-102 PMID: 12556913
  158. The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders.
    JAMA. 1991 Oct 2;266(13):1793-800 PMID: 1832466
  159. Investigation of variation in SNAP-25 and ADHD and relationship to co-morbid major depressive disorder.
    Am J Med Genet B Neuropsychiatr Genet. 2007 Sep 5;144B(6):781-90 PMID: 17455213
  160. Further evidence of the involvement of alpha-2A-adrenergic receptor gene (ADRA2A) in inattentive dimensional scores of attention-deficit/hyperactivity disorder.
    Mol Psychiatry. 2006 Jan;11(1):8-10 PMID: 16172611
  161. Synaptosomal-associated protein 25 (SNAP-25) and attention deficit hyperactivity disorder (ADHD): evidence of linkage and association in the Irish population.
    Mol Psychiatry. 2002;7(8):913-7 PMID: 12232787
  162. Genome-wide association scan of attention deficit hyperactivity disorder.
    Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1337-44 PMID: 18980221
  163. Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder in Chinese Han population.
    Am J Med Genet B Neuropsychiatr Genet. 2006 Mar 5;141B(2):126-9 PMID: 16389593
Article Info
Journal
The Psychiatric clinics of North America
Abbr.
Psychiatr Clin North Am
ISSN
1558-3147
DOI
10.1016/j.psc.2009.12.004
Email
[email protected]
Published
2010-03-00
Pages
159-80
Language
English
Region
United States
NLM ID
7708110
PMCID
PMC2847260
Subset
IM
Grants
NIMH NIH HHS · R01 MH066877 · United States
NIMH NIH HHS · R01 MH066877-08 · United States
NIMH NIH HHS · R13 MH059126 · United States
NIMH NIH HHS · R13 MH059126-11 · United States
External Links
PubMed source DOI: 10.1016/j.psc.2009.12.004 PMC Full Text View journal details
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