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PMID: 20200537 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

PARP inhibition: PARP1 and beyond.

Nature reviews. Cancer ·Vol. 10 ·No. 4 ·2010-04-00 ·Pages 293-301

Rouleau M, Patel A, Hendzel MJ, Kaufmann SH, Poirier GG

Abstract

Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide the rational development of PARP inhibitors as anticancer agents.

MeSH Terms
Animals Antineoplastic Agents/therapeutic use Cell Death DNA Damage DNA, Neoplasm/genetics Dacarbazine/analogs & derivatives,therapeutic use Deoxycytidine/analogs & derivatives,therapeutic use Humans Kinetics Mice Neoplasms/enzymology,pathology Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases/genetics,metabolism,therapeutic use Substrate Specificity Temozolomide
Chemicals
Antineoplastic Agents DNA, Neoplasm Poly(ADP-ribose) Polymerase Inhibitors Deoxycytidine Dacarbazine gemcitabine PARP1 protein, human Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases Temozolomide
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Rouleau Michèle
Laval University Medical Research Center, Laval University, Québec, Canada.
Patel Anand
Hendzel Michael J
Kaufmann Scott H
Poirier Guy G
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc2812
Published
2010-04-00
Epub
2010-00-04
Pages
293-301
Language
English
Region
England
NLM ID
101124168
PMCID
PMC2910902
Subset
IM
Grants
NCI NIH HHS · P50 CA136393-01 · United States
Canadian Institutes of Health Research · MOP-74648 · Canada
Canadian Institutes of Health Research · IG1-14052 · Canada
NCI NIH HHS · P50 CA136393-01A1 · United States
NCI NIH HHS · P50 CA136393 · United States
NIGMS NIH HHS · T32 GM072474 · United States
External Links
PubMed source DOI: 10.1038/nrc2812 PMC Full Text View journal details
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