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PMID: 20559679 Published · ppublish English Journal Article Review

One lipid, multiple functions: how various pools of PI(4,5)P(2) are created in the plasma membrane.

Cellular and molecular life sciences : CMLS ·Vol. 67 ·No. 23 ·2010-12-00 ·Pages 3927-46

Kwiatkowska K

Abstract

Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)] is a minor lipid of the inner leaflet of the plasma membrane that controls the activity of numerous proteins and serves as a source of second messengers. This multifunctionality of PI(4,5)P(2) relies on mechanisms ensuring transient appearance of PI(4,5)P(2) clusters in the plasma membrane. One such mechanism involves phosphorylation of PI(4)P to PI(4,5)P(2) by the type I phosphatidylinositol-4-phosphate 5-kinases (PIP5KI) at discrete membrane locations coupled with PI(4)P delivery/synthesis at the plasma membrane. Simultaneously, both PI(4)P and PI(4,5)P(2) participate in anchoring PIP5KI at the plasma membrane via electrostatic bonds. PIP5KI isoforms are also selectively recruited and activated at the plasma membrane by Rac1, talin, or AP-2 to generate PI(4,5)P(2) in ruffles and lamellipodia, focal contacts, and clathrin-coated pits. In addition, PI(4,5)P(2) can accumulate at sphingolipid/cholesterol-based rafts following activation of distinct membrane receptors or be sequestered in a reversible manner due to electrostatic constrains posed by proteins like MARCKS.

MeSH Terms
Adaptor Protein Complex 2/metabolism Amino Acid Sequence Animals Cell Membrane/chemistry,metabolism,ultrastructure Coated Pits, Cell-Membrane/metabolism Focal Adhesions/metabolism Humans Isoenzymes/genetics,metabolism Molecular Sequence Data Phosphatidylinositol 4,5-Diphosphate/metabolism Phosphotransferases (Alcohol Group Acceptor)/genetics,metabolism Sequence Alignment Talin/metabolism
Chemicals
Adaptor Protein Complex 2 Isoenzymes Phosphatidylinositol 4,5-Diphosphate Talin Phosphotransferases (Alcohol Group Acceptor) 1-phosphatidylinositol-4-phosphate 5-kinase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kwiatkowska Katarzyna
Laboratory of Plasma Membrane Receptors, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warsaw, Poland. [email protected]
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Article Info
Journal
Cellular and molecular life sciences : CMLS
Abbr.
Cell Mol Life Sci
ISSN
1420-9071
DOI
10.1007/s00018-010-0432-5
Email
[email protected]
Published
2010-12-00
Epub
2010-00-18
Pages
3927-46
Language
English
Region
Switzerland
NLM ID
9705402
Subset
IM
External Links
PubMed source DOI: 10.1007/s00018-010-0432-5 View journal details
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