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PMID: 21258395 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

DNA polymerases and cancer.

Nature reviews. Cancer ·Vol. 11 ·No. 2 ·2011-02-00 ·Pages 96-110

Lange SS, Takata K, Wood RD

Abstract

There are 15 different DNA polymerases encoded in mammalian genomes, which are specialized for replication, repair or the tolerance of DNA damage. New evidence is emerging for lesion-specific and tissue-specific functions of DNA polymerases. Many point mutations that occur in cancer cells arise from the error-generating activities of DNA polymerases. However, the ability of some of these enzymes to bypass DNA damage may actually defend against chromosome instability in cells, and at least one DNA polymerase, Pol ζ, is a suppressor of spontaneous tumorigenesis. Because DNA polymerases can help cancer cells tolerate DNA damage, some of these enzymes might be viable targets for therapeutic strategies.

MeSH Terms
Cell Transformation, Neoplastic/genetics DNA Repair DNA-Directed DNA Polymerase/genetics,metabolism Gene Expression Regulation, Neoplastic Humans Molecular Targeted Therapy Neoplasms/genetics
Chemicals
DNA-Directed DNA Polymerase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lange Sabine S
Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center Science Park and the Graduate School of Biomedical Sciences at Houston, Texas, USA.
Takata Kei-ichi
Wood Richard D
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc2998
Published
2011-02-00
Pages
96-110
Language
English
Region
England
NLM ID
101124168
PMCID
PMC3739438
Subset
IM
Grants
NCI NIH HHS · P30 CA016672 · United States
NCI NIH HHS · CA09717 · United States
NCI NIH HHS · CA132840 · United States
NIEHS NIH HHS · P30ES007784 · United States
NCI NIH HHS · R01 CA132840 · United States
NIEHS NIH HHS · P30 ES007784 · United States
NCI NIH HHS · P01 CA097175 · United States
NCI NIH HHS · P30-CA016672 · United States
External Links
PubMed source DOI: 10.1038/nrc2998 PMC Full Text View journal details
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