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PMID: 21296675 Published · ppublish English Clinical Trial, Phase II Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Reduced-intensity allogeneic transplantation provides high event-free and overall survival in patients with advanced indolent B cell malignancies: CALGB 109901.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation ·Vol. 17 ·No. 9 ·2011-09-00 ·Pages 1395-403

Shea T, Johnson J, Westervelt P, Farag S, McCarty J, Bashey A, Isola L, Baxter-Lowe LA, Kelly M, Owzar K, Linker C, Cancer and Leukemia Group B

Abstract

Cancer and Leukemia Group B conducted a phase II study to evaluate the safety and efficacy of a reduced-intensity conditioning regimen with allogeneic transplantation to treat patients with recurrent low-grade B cell malignancies. Patients over age 18 with a diagnosis of relapsed, chemotherapy-sensitive disease underwent transplantation with a matched sibling donor, and conditioning with cyclophosphamide (1 g/m(2)/day × 3) and fludarabine phosphate (25 mg/m(2)/day × 5). Graft-versus-host prophylaxis included cyclosporine or tacrolimus plus low-dose methotrexate. Forty-four evaluable patients with a median age of 53 and median of 2 prior regimens were accrued. Sixteen patients had follicular non-Hodgkin lymphoma and 28 had histologies including 7 indolent B cell lymphomas, 4 mantle cell, 15 chronic lymphocytic leukemia (CLL), and 2 prolymphocytic leukemia (PLL) patients. The 6-month treatment-related mortality (TRM) was 2.4% and 3-year TRM was 9%. Three-year event-free and overall survival were 0.75 and 0.81 for the follicular patients, 0.59 and 0.71 for the CLL/PLL patients, and 0.55 and 0.64 for the other histologies. The incidence of grade II-IV acute graft-versus-host disease (GVHD) was 29%, and extensive chronic GVHD was 18%. This report demonstrates that allogeneic sibling transplantation with a reduced-intensity conditioning regimen is safe and efficacious for patients with advanced indolent B cell malignancies enrolled on a Cooperative Group study.

MeSH Terms
Adult Aged Antineoplastic Agents/administration & dosage,therapeutic use Cyclophosphamide/therapeutic use Dose-Response Relationship, Drug Female Hematopoietic Stem Cell Transplantation/methods,mortality Humans Leukemia, B-Cell/mortality,therapy Lymphoma, B-Cell/mortality,therapy Male Middle Aged Survival Rate Transplantation Conditioning/methods Transplantation, Homologous Treatment Outcome Vidarabine Phosphate/analogs & derivatives,therapeutic use
Chemicals
Antineoplastic Agents Vidarabine Phosphate fludarabine phosphate Cyclophosphamide
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Shea Thomas
University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA. [email protected]
Johnson Jeffrey
Westervelt Peter
Farag Sherif
McCarty John
Bashey Asad
Isola Luis
Baxter-Lowe Lee-Anne
Kelly Michael
Owzar Kouros
Linker Charles
Cancer and Leukemia Group B
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Article Info
Journal
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Abbr.
Biol Blood Marrow Transplant
ISSN
1523-6536
Published
2011-09-00
Epub
2011-00-03
Pages
1395-403
Language
English
Region
United States
NLM ID
9600628
PMCID
PMC3134602
Subset
IM
Grants
NCI NIH HHS · U10 CA059518 · United States
NCI NIH HHS · U10 CA047559 · United States
NCI NIH HHS · CA47559 · United States
NCI NIH HHS · CA77658 · United States
NCI NIH HHS · CA37135 · United States
NCI NIH HHS · CA33601 · United States
NCI NIH HHS · CA77597 · United States
NCI NIH HHS · CA04457 · United States
NCI NIH HHS · CA11789 · United States
NCI NIH HHS · U10 CA077658 · United States
NCI NIH HHS · CA03927 · United States
NCI NIH HHS · U10 CA031946 · United States
NCI NIH HHS · U10 CA033601 · United States
NCI NIH HHS · U10 CA047559-21 · United States
NCI NIH HHS · CA59518 · United States
NCI NIH HHS · CA60138 · United States
NCI NIH HHS · U10 CA077597 · United States
NCI NIH HHS · CA31946 · United States
NCI NIH HHS · U10 CA003927 · United States
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