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PMID: 21297381 Published · ppublish English Journal Article Review

Environmental triggers of thyroiditis: hepatitis C and interferon-α.

Journal of endocrinological investigation ·Vol. 34 ·No. 1 ·2011-01-00 ·Pages 78-84

Menconi F, Hasham A, Tomer Y

Abstract

Autoimmune thyroid diseases (AITD) are postulated to develop as a result of a complex interplay between several genetic and environmental influences. The pathogenesis of AITD is still not clearly defined. However, among the implicated triggers (e.g. iodine, infections, medications), more recent data confirmed strong associations of AITD with the hepatitis C virus (HCV) infection and interferon-α (IFNα) therapy. Moreover, it is likely that HCV and IFN act in synergism to trigger AITD in patients. Indeed, approximately 40% of HCV patients develop either clinical or subclinical disease while receiving IFNα. Interferon induced thyroiditis (IIT) can manifest as non-autoimmune thyroiditis (presenting as destructive thyroiditis, or non-autoimmune hypothyroidism), or autoimmune thyroiditis [presenting with clinical features of Graves' disease (GD) or Hashimoto's thyroiditis (HT)]. Although not yet clearly understood, it is thought that IFNα can induce thyroiditis via both immune stimulatory and direct toxic effects on the thyroid. In view of the high frequency of IIT, routine screening and surveillance of HCV patients receiving IFNα is recommended to avoid the complications, such as cardiac arrhythmias, associated with thyrotoxicosis. In summary, IIT is a common clinical problem that can be readily diagnosed with routine thyroid function screening of HCV patients receiving IFN. The treatment of IIT consists of the standard therapy for differing clinical manifestations of IIT such as GD, HT, or destructive thyroiditis. However, anti-thyroid medications are not recommended in this setting since they can potentially be hepatotoxic.

MeSH Terms
Animals Environment Genetic Predisposition to Disease Hepatitis C/complications,genetics Humans Interferon-alpha/adverse effects,physiology Models, Biological Thyroiditis/diagnosis,etiology,genetics,therapy
Chemicals
Interferon-alpha
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Menconi F
Division of Endocrinology, Department of Medicine, Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY 10029, USA. [email protected]
Hasham A
Tomer Y
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Article Info
Journal
Journal of endocrinological investigation
Abbr.
J Endocrinol Invest
ISSN
1720-8386
Published
2011-01-00
Epub
2010-00-28
Pages
78-84
Language
English
Region
Italy
NLM ID
7806594
Subset
IM
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