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PMID: 21513695 Published · ppublish English Journal Article Review

Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme.

Archives of biochemistry and biophysics ·Vol. 510 ·No. 2 ·2011-06-15 ·Pages 93-100

Wirschell M, Yamamoto R, Alford L, Gokhale A, Gaillard A, Sale WS

Abstract

Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9+2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.

MeSH Terms
Animals Axoneme/enzymology,metabolism Cilia/enzymology,metabolism Conserved Sequence Humans Movement Phosphoric Monoester Hydrolases/chemistry,metabolism Protein Kinases/chemistry,metabolism
Chemicals
Protein Kinases Phosphoric Monoester Hydrolases
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Wirschell Maureen
Emory University School of Medicine, Department of Cell Biology, Atlanta, GA 30322, USA. [email protected]
Yamamoto Ryosuke
Alford Lea
Gokhale Avanti
Gaillard Anne
Sale Winfield S
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Article Info
Journal
Archives of biochemistry and biophysics
Abbr.
Arch Biochem Biophys
ISSN
1096-0384
DOI
10.1016/j.abb.2011.04.003
Email
[email protected]
Published
2011-06-15
Epub
2011-00-14
Pages
93-100
Language
English
Region
United States
NLM ID
0372430
PMCID
PMC3114296
Subset
IM
Grants
NIGMS NIH HHS · R01 GM051173 · United States
NIGMS NIH HHS · R37 GM051173 · United States
NIGMS NIH HHS · R37 GM051173-27 · United States
External Links
PubMed source DOI: 10.1016/j.abb.2011.04.003 PMC Full Text View journal details
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