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PMID: 2170666 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Single copy sequences in galago DNA resemble a repetitive human retrotransposon-like family.

Journal of molecular evolution ·Vol. 31 ·No. 2 ·1990-08-00 ·Pages 92-100

Schmid CW, Wong EF, Deka N

Abstract

Galago DNA contains a few single copy sequences that are homologous to the human THE 1 family of repeats. Two of these galago loci have been isolated as genomic clones and their structures are compared to the THE 1 consensus sequence. Whereas the human sequence resembles a proretroviral transposon, the galago sequences provide no evidence for a proretroviral sequence organization. The two galago clones share a common repeat sequence, which is homologous to the U5 region of the THE 1 long terminal repeat. Immediately 3' to this repeat, each galago clone contains sequences that are homologous to mutually exclusive regions of the internal THE 1 sequence. Thus, the human THE 1 sequence can be represented as a mosaic of the two ancestrally related galago loci. The galago loci are transcribed in vivo, so that their conservation in the primate genome could be selected. Human THE 1 repeats apparently resulted by recruiting preexisting cellular sequences via a retrovirally mediated process.

MeSH Terms
Animals Bacteriophage lambda/genetics Base Sequence Biological Evolution DNA/analysis DNA Transposable Elements Galago/genetics Humans In Vitro Techniques Molecular Sequence Data Mutation Repetitive Sequences, Nucleic Acid Restriction Mapping Retroviridae/genetics Sequence Homology, Nucleic Acid Transcription, Genetic
Chemicals
DNA Transposable Elements DNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Schmid C W
Department of Chemistry, University of California, Davis 95616.
Wong E F
Deka N
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19 references, click to expand
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Article Info
Journal
Journal of molecular evolution
Abbr.
J Mol Evol
ISSN
0022-2844
DOI
10.1007/BF02109478
Published
1990-08-00
Pages
92-100
Language
English
Region
Germany
NLM ID
0360051
Subset
IM
Grants
NIGMS NIH HHS · GM-21346 · United States
External Links
PubMed source DOI: 10.1007/BF02109478 View journal details
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